Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, Turku, FI-20520, Finland; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5E), University of Helsinki, FI-00014, Finland.
Bayer Oy, Pansiontie 47, Turku, Finland.
Int J Pharm. 2018 Jun 15;544(2):433-442. doi: 10.1016/j.ijpharm.2017.11.016. Epub 2017 Nov 9.
The goal of this work was to study the printability of PDMS with a semi-solid extrusion printer in combination with the UV-assisted crosslinking technology using UV-LED light to manufacture drug containing structures. Structures with different pore sizes and different drug loadings were prepared containing prednisolone as a model drug. The work showed that it was possible to print drug-free and drug-loaded drug delivery devices of PDMS with the 3D printing technique used in this study. The required UV-curing time to get sufficient crosslinking yield and mechanical strength was minimum three minutes. The microgram drug release from the printed structures was highest for the most drug loaded structures regardless of the porosity of the devices. By altering the surface area/volume ratio it was possible to print structures with differences in the release rate. This study shows that room-temperature semi-solid extrusion printing 3D printing technique in combination with UV-LED crosslinking is an applicable method in the production of prednisolone containing PDMS devices. Both the extrusion 3D printing and the UV-crosslinking was done at room temperature, which make this manufacturing method an interesting alternative for manufacturing controlled release devices containing temperature susceptible drugs.
这项工作的目的是研究 PDMS 的可印刷性，使用半固态挤出打印机结合 UV 辅助交联技术，使用 UV-LED 光制造含有药物的结构。制备了具有不同孔径和不同载药量的结构，其中含有作为模型药物的泼尼松龙。研究结果表明，使用本研究中使用的 3D 打印技术，可以打印无药物和载药的 PDMS 药物输送装置。获得足够交联产率和机械强度所需的 UV 固化时间最短为三分钟。从打印结构中释放的微克药物对于载药量最高的结构最高，而与装置的孔隙率无关。通过改变表面积/体积比，可以打印出释放速率不同的结构。这项研究表明，室温半固态挤出 3D 打印技术与 UV-LED 交联相结合是生产含有泼尼松龙的 PDMS 装置的一种适用方法。挤出 3D 打印和 UV 交联都是在室温下进行的，这使得这种制造方法成为制造含有对温度敏感药物的控释装置的一种有趣的替代方法。
