Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany; German Center for Lung Research, Munich, Germany; German Centre for Cardiovascular Research, Munich Heart Alliance, Munich, Germany.
Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany; German Center for Lung Research, Munich, Germany; German Centre for Cardiovascular Research, Munich Heart Alliance, Munich, Germany.
Pharmacol Ther. 2018 Apr;184:159-176. doi: 10.1016/j.pharmthera.2017.11.003. Epub 2017 Nov 9.
Transient receptor potential (TRP) proteins TRPM6 and TRPM7 are α-kinase-coupled divalent cation-selective channels activated upon a reduction of cytosolic levels of Mg and Mg·ATP. Emerging evidence indicate that one of the main physiological functions of TRPM6 and TRPM7 is maintaining of cellular metabolism of Mg and likely other essential metals such as Ca and Zn. Recent experiments with genetic animal models have shown that TRPM6 and TRPM7 are essential for epithelial Mg transport in the placenta and intestine. In addition, mutations in TRPM6 or TRPM7 have been linked to Mg deficiency in humans. However, many key functional aspects of these remarkable proteins as well as mechanisms of the associated channelopathies remain incompletely understood. The present review article highlights the recent significant progress in the field with the focus on the vital roles of TRPM7 and TRPM7 in mineral homeostasis.
瞬时受体电位 (TRP) 蛋白 TRPM6 和 TRPM7 是 α-激酶偶联的二价阳离子选择性通道，在细胞质中 Mg 和 Mg·ATP 水平降低时被激活。新出现的证据表明，TRPM6 和 TRPM7 的主要生理功能之一是维持细胞内的 Mg 代谢以及可能的其他必需金属，如 Ca 和 Zn。最近利用遗传动物模型的实验表明，TRPM6 和 TRPM7 对于胎盘和肠道中的上皮细胞 Mg 转运是必需的。此外，TRPM6 或 TRPM7 的突变与人类的 Mg 缺乏有关。然而，这些显著蛋白质的许多关键功能方面以及相关通道病的机制仍不完全清楚。本文综述了该领域的最新重要进展，重点介绍了 TRPM7 和 TRPM7 在矿物质稳态中的重要作用。
