Ciaglia Tania, Vestuto Vincenzo, Bertamino Alessia, González-Muñiz Rosario, Gómez-Monterrey Isabel
Dipartimento di Farmacia (DIFARMA), Università degli Studi di Salerno, Fisciano, Italy.
Departamento de Biomiméticos, Instituto de Química Médica, Madrid, Spain.
Front Oncol. 2023 Feb 9;12:1065935. doi: 10.3389/fonc.2022.1065935. eCollection 2022.
The transient melastatin receptor potential (TRPM) ion channel subfamily functions as cellular sensors and transducers of critical biological signal pathways by regulating ion homeostasis. Some members of TRPM have been cloned from cancerous tissues, and their abnormal expressions in various solid malignancies have been correlated with cancer cell growth, survival, or death. Recent evidence also highlights the mechanisms underlying the role of TRPMs in tumor epithelial-mesenchymal transition (EMT), autophagy, and cancer metabolic reprogramming. These implications support TRPM channels as potential molecular targets and their modulation as an innovative therapeutic approach against cancer. Here, we discuss the general characteristics of the different TRPMs, focusing on current knowledge about the connection between TRPM channels and critical features of cancer. We also cover TRPM modulators used as pharmaceutical tools in biological trials and an indication of the only clinical trial with a TRPM modulator about cancer. To conclude, the authors describe the prospects for TRPM channels in oncology.
瞬时褪黑素受体电位（TRPM）离子通道亚家族通过调节离子稳态，作为关键生物信号通路的细胞传感器和转导器发挥作用。TRPM的一些成员已从癌组织中克隆出来，它们在各种实体恶性肿瘤中的异常表达与癌细胞的生长、存活或死亡相关。最近的证据还突出了TRPM在肿瘤上皮-间质转化（EMT）、自噬和癌症代谢重编程中作用的潜在机制。这些发现支持将TRPM通道作为潜在的分子靶点，并将其调节作为一种创新的抗癌治疗方法。在此，我们讨论不同TRPM的一般特征，重点关注关于TRPM通道与癌症关键特征之间联系的当前知识。我们还涵盖了在生物学试验中用作药物工具的TRPM调节剂，以及唯一一项关于癌症的TRPM调节剂临床试验的情况。最后，作者描述了TRPM通道在肿瘤学中的前景。
