Lipids and Atherosclerosis Unit, GC9 Nutrigenomics, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Córdoba, Spain.
Exp Gerontol. 2018 Aug;109:119-125. doi: 10.1016/j.exger.2017.11.006. Epub 2017 Nov 10.
Aging is an important determinant of the rate of atherosclerosis development, mainly through low-grade inflammation. Diet, and particularly its fat content, modulates the inflammatory response in fasting and postprandial states.
We aimed to study the effects of dietary fat on endotoxemia in healthy older adults.
Twenty healthy older adults were randomized to three diets, lasting three-weeks each, using a crossover design: 1. A Mediterranean diet enriched in MUFA with virgin olive oil. 2. An SFA-rich diet. 3. A low-fat high-carbohydrate diet enriched in n-3 PUFA (α-linolenic acid of plant origin) (CHO-PUFA diet). At the end of each period, after a 12-h fast, the subjects received a meal with a composition similar to the dietary period just completed. We determined the fasting and the postprandial plasma levels of lipopolysaccharide (LPS) and LPS-binding protein (LBP).
In the fasting state, we observed lower LPS plasma levels after the consumption of the CHO-PUFA diet (P=0.046) in comparison with the consumption of the Med and SFA-rich diets. In the postprandial measurements, we observed a statistically significant increase in plasma levels of LPS (P=0.044) and a decrease in LBP (P=0.003) after the intake of the CHO-PUFA meal, whereas no postprandial changes were observed after the ingestion of the Med and SFA-rich meals.
Our results, together with those obtained in a previous study, support the concept that the consumption of the Med Diet, in contrast to a low-fat PUFA diet, constitutes a more suitable dietary lifestyle for preventing the development of atherosclerosis in a population at risk, such as older adults.
衰老主要通过低水平炎症，是动脉粥样硬化发展速度的重要决定因素。饮食，尤其是其脂肪含量，调节空腹和餐后状态下的炎症反应。
我们旨在研究饮食脂肪对健康老年人内毒素血症的影响。
20 名健康老年人采用交叉设计随机分为三组，分别接受三种饮食，持续 3 周：1. 富含 MUFA 的地中海饮食，使用特级初榨橄榄油。2. SFA 丰富的饮食。3. 富含 n-3 PUFA（植物来源的α-亚麻酸）的低脂高碳水化合物饮食（CHO-PUFA 饮食）。在每个周期结束时，禁食 12 小时后，受试者接受与刚刚完成的饮食周期组成相似的膳食。我们测定空腹和餐后血浆内毒素（LPS）和 LPS 结合蛋白（LBP）水平。
在禁食状态下，与食用 Med 和 SFA 丰富饮食相比，CHO-PUFA 饮食后血浆 LPS 水平较低（P=0.046）。在餐后测量中，我们观察到 CHO-PUFA 餐后血浆 LPS 水平（P=0.044）显著升高，LBP 水平（P=0.003）降低，而食用 Med 和 SFA 丰富膳食后则没有餐后变化。
我们的结果与之前的研究结果一起支持这样的概念，即与低脂肪 PUFA 饮食相比，食用 Med 饮食构成了一种更适合预防高危人群（如老年人）动脉粥样硬化发展的饮食生活方式。
