Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Palayad, Kannur, Kerala, 670 661, India.
Molecular Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud, P. O., Thiruvananthapuram, Kerala, 695 014, India.
J Chem Neuroanat. 2019 Jan;95:95-114. doi: 10.1016/j.jchemneu.2017.11.008. Epub 2017 Nov 9.
Aging in the biological system is an irreversible process. In the initial stages of lifespan aging improves survival skills of an organism while in the later stages aging reduce the survival skills. Aging is associated with changes in several cellular and molecular functions among which calcium signaling is a prominent one. Calcium signaling is essential for many vital functions of the brain and even minor impairments in calcium signaling can lead to deleterious consequences including neuronal death. Calcium signaling proteins are pursued as promising drug targets for many aging related diseases. This review attempts to summarize changes in calcium signaling in the brain as a result of aging.
生物系统中的衰老过程是不可逆转的。在生命周期的早期，衰老可以提高生物体的生存技能，而在后期，衰老则会降低生存技能。衰老是与几种细胞和分子功能的变化相关的，其中钙信号转导是一个突出的功能。钙信号转导对于大脑的许多重要功能是必不可少的，即使钙信号转导的微小损伤也可能导致有害的后果，包括神经元死亡。钙信号转导蛋白被认为是许多与衰老相关疾病的有前途的药物靶点。本综述试图总结大脑中钙信号转导随衰老而发生的变化。
