志愿者对源自两种不同禽流感病毒供体的活禽-人甲型H3N2重组病毒疫苗的病毒学和免疫学反应比较。
Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors.
作者信息
Clements M L, Sears S D, Christina K, Murphy B R, Snyder M H
机构信息
Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205.
出版信息
J Clin Microbiol. 1989 Jan;27(1):219-22. doi: 10.1128/jcm.27.1.219-222.1989.
Abstract
We compared the abilities of the six internal RNA segments of two avian influenza viruses, A/Mallard/Alberta/88/76 (H3N8) and A/Mallard/NY/6750/78 (H2N2), to confer attenuation on wild-type human influenza A/Bethesda/1/85 (H3N2) virus in seronegative adult volunteers. Live avian-human influenza A reassortant virus vaccines derived from either avian virus parent were comparable in the following properties: safety, infectivity, immunogenicity, and genetic stability. Since the avian influenza A/Mallard/Alberta/76 virus offered no clear advantage as a donor virus, we will conduct our future evaluations on live influenza A virus reassortants derived from the more extensively characterized avian influenza A/Mallard/NY/78 virus.
摘要
我们比较了两种禽流感病毒A/野鸭/艾伯塔/88/76（H3N8）和A/野鸭/纽约/6750/78（H2N2）的六个内部RNA片段，在血清阴性成年志愿者中使野生型人甲型流感病毒A/贝塞斯达/1/85（H3N2）减毒的能力。源自任一禽病毒亲本的活禽-人甲型流感重组病毒疫苗在以下特性方面具有可比性：安全性、感染性、免疫原性和遗传稳定性。由于禽流感A/野鸭/艾伯塔/76病毒作为供体病毒没有明显优势，我们将对源自特征更广泛的禽流感A/野鸭/纽约/78病毒的活甲型流感病毒重组体进行未来评估。
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Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors.志愿者对源自两种不同禽流感病毒供体的活禽-人甲型H3N2重组病毒疫苗的病毒学和免疫学反应比较。
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