对源自不同禽流感病毒供体的禽-人流感 A 病毒重配体在松鼠猴、黑猩猩和成年人类中的研究比较。
Comparison by studies in squirrel monkeys, chimpanzees, and adult humans of avian-human influenza A virus reassortants derived from different avian influenza virus donors.
作者信息
Snyder M H, Clements M L, Herrington D, London W T, Tierney E L, Murphy B R
出版信息
J Clin Microbiol. 1986 Sep;24(3):467-9. doi: 10.1128/jcm.24.3.467-469.1986.
Abstract
We evaluated the abilities of three different avian influenza A viruses to attenuate the wild-type human influenza A/Korea/1/82 (H3N2) virus in squirrel monkeys, chimpanzees, and adult seronegative human volunteers. Two of these, avian influenza A/Mallard/NY/78 and A/Mallard/Alberta/76 viruses, appeared to be satisfactory donors of attenuating genes for the production of live influenza A reassortant virus vaccines for human use because the reassortants exhibited an acceptable balance between attenuation and immunogenicity.
摘要
我们评估了三种不同的甲型禽流感病毒在松鼠猴、黑猩猩和成年血清阴性人类志愿者体内使野生型甲型人类流感病毒A/韩国/1/82（H3N2）减毒的能力。其中两种病毒，甲型禽流感病毒A/绿头鸭/纽约/78和A/绿头鸭/艾伯塔/76，似乎是生产供人类使用的甲型流感重组活病毒疫苗的减毒基因的理想供体，因为重组病毒在减毒和免疫原性之间表现出了可接受的平衡。
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