Medical Physics and Engineering, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, LS9 7TF, United Kingdom.
Phys Med Biol. 2017 Dec 19;63(1):015021. doi: 10.1088/1361-6560/aa9a1f.
Flattening filter free (FFF) beams have reached widespread use for clinical treatment deliveries. The usual methods for FFF beam characterisation for their quality assurance (QA) require the use of associated conventional flattened beams (cFF). Methods for QA of FFF without the need to use associated cFF beams are presented and evaluated against current methods for both FFF and cFF beams. Inflection point normalisation is evaluated against conventional methods for the determination of field size and penumbra for field sizes from 3 cm × 3 cm to 40 cm × 40cm at depths from dmax to 20 cm in water for matched and unmatched FFF beams and for cFF beams. A method for measuring symmetry in the cross plane direction is suggested and evaluated as FFF beams are insensitive to symmetry changes in this direction. Methods for characterising beam energy are evaluated and the impact of beam energy on profile shape compared to that of cFF beams. In-plane symmetry can be measured, as can cFF beams, using observed changes in profile, whereas cross-plane symmetry can be measured by acquiring profiles at collimator angles 0 and 180. Beam energy and 'unflatness' can be measured as with cFF beams from observed shifts in profile with changing beam energy. Normalising the inflection points of FFF beams to 55% results in an equivalent penumbra and field size measurement within 0.5 mm of conventional methods with the exception of 40 cm × 40 cm fields at a depth of 20 cm. New proposed methods are presented that make it possible to independently carry out set up and QA measurements on beam energy, flatness, symmetry and field size of an FFF beam without the need to reference to an equivalent flattened beam of the same energy. The methods proposed can also be used to carry out this QA for flattened beams, resulting in universal definitions and methods for MV beams. This is presented for beams produced by an Elekta linear accelerator, but is anticipated to also apply to other manufacturers' beams.
FFF 无均整过滤器(flattening filter free,FFF)光束已广泛应用于临床治疗。通常需要使用相关的常规平化(conventional flattened,cFF)光束来对 FFF 光束特性进行质量保证(quality assurance,QA)。本研究提出了一种无需使用相关 cFF 光束的 FFF 光束 QA 方法,并对其与现有的 FFF 和 cFF 光束 QA 方法进行了评估。拐点归一化(inflection point normalisation)用于评估常规方法确定 3cm×3cm 至 40cm×40cm 大小的射野在水模中从 dmax 到 20cm 深度的射野大小和半影,包括匹配和不匹配的 FFF 光束以及 cFF 光束。提出了一种用于测量横平面方向对称性的方法,并对其进行了评估,因为 FFF 光束对此方向的对称性变化不敏感。评估了用于描述光束能量的方法,并将其与 cFF 光束的轮廓形状进行了比较。与 cFF 光束一样,可以通过观察轮廓变化来测量平面内对称性,而可以通过在准直器角度 0 和 180 处采集轮廓来测量横平面对称性。可以像 cFF 光束一样,通过观察随光束能量变化的轮廓偏移来测量 FFF 光束的能量和“不均匀度”。将 FFF 光束的拐点归一化为 55%,可在与常规方法 0.5mm 以内的等效半影和射野大小测量值,除了在 20cm 深度处的 40cm×40cm 射野。本研究提出了新的方法,可以独立进行 FFF 光束的设置和 QA 测量,包括光束能量、平坦度、对称性和射野大小,而无需参考相同能量的等效平化光束。提出的方法也可用于进行平化光束的 QA,从而为 MV 光束提供通用的定义和方法。本研究结果适用于 Elekta 直线加速器产生的光束,但预计也适用于其他制造商的光束。