Bohn Barbara, Wiegand Susanna, Kiess Wieland, Reinehr Thomas, Stachow Rainer, Oepen Johannes, Langhof Helmut, Hermann Thomas, Widhalm Kurt, Wabitsch Martin, Gellhaus Ines, Holl Reinhard
University of Ulm, Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm, Germany.
Obes Facts. 2017;10(5):517-530. doi: 10.1159/000479631. Epub 2017 Oct 31.
To examine whether characteristics of children and adolescents who start lifestyle intervention (LI) for obesity in Germany changed over the last decade.
65,453 subjects (<21 years) from the APV database (Adiposity Patients Registry) with a BMI ≥ 90th percentile were included (years 2005-2015). Logistic regression models (confounders: age, sex, migration background) were created for overweight, obesity, extreme obesity, and obesity-related comorbidities. Comorbidities were further adjusted for weight category. Results were stratified by inpatient or outpatient care.
Extreme obesity was found to be more frequent at the onset of LI (2005: 11.6; 2015: 12.7%) with a similar trend in subgroups (p < 0.001). Obesity increased (2005: 50.3%; 2015: 55.1%), and overweight decreased (2005: 34.1%; 2015: 29.0%) in the whole study population. Trends were similar for inpatient or outpatient care (all p < 0.001). Hypertension increased from 45.7% to 49.2% in the whole study population, and similar data were obtained in the subgroup of inpatients (both p < 0.0001). Dyslipidemia increased in all patients (2005: 21.9%; 2015: 28.0%) and in inpatients (2005: 20.2%; 2015: 25.7%; both p < 0.0001). Abnormal carbohydrate metabolism rose in all patients (from 5.2 to 6.4%; p = 0.0002) without significant trends in subgroups.
During the last decade, children and adolescents presented with higher BMI SDS at the onset of LI and the proportion with obesity-related comorbidities increased. Particularly the presence of comorbidities differed between outpatients and inpatients.
研究过去十年间,德国开始接受肥胖生活方式干预(LI)的儿童及青少年的特征是否发生了变化。
纳入来自APV数据库(肥胖患者登记处)的65453名年龄小于21岁、BMI≥第90百分位数的受试者(2005年至2015年)。针对超重、肥胖、极度肥胖及肥胖相关合并症建立逻辑回归模型(混杂因素:年龄、性别、移民背景)。合并症进一步根据体重类别进行调整。结果按住院或门诊治疗进行分层。
发现极度肥胖在LI开始时更为常见(2005年:11.6%;2015年:12.7%),各亚组趋势相似(p<0.001)。在整个研究人群中,肥胖率上升(2005年:50.3%;2015年:55.1%),超重率下降(2005年:34.1%;2015年:29.0%)。住院或门诊治疗的趋势相似(所有p<0.001)。整个研究人群中高血压从45.7%增至49.2%,住院亚组也得到类似数据(两者p<0.0001)。所有患者血脂异常均增加(2005年:21.9%;2015年:28.0%),住院患者也是如此(2005年:20.2%;2015年:25.7%;两者p<0.0001)。所有患者碳水化合物代谢异常有所上升(从5.2%至6.4%;p=0.0002),各亚组无显著趋势。
在过去十年间,儿童及青少年在LI开始时BMI SDS更高,且肥胖相关合并症的比例增加。尤其是门诊患者和住院患者的合并症情况有所不同。