The Morbid Obesity Centre (MOC), Department of Medicine, Vestfold Hospital Trust, Tønsberg, Norway.
Faculty of Medicine, University of Oslo, Oslo, Norway.
Acta Paediatr. 2019 Mar;108(3):493-501. doi: 10.1111/apa.14542. Epub 2018 Sep 17.
We aimed to compare modifiable cardiometabolic risk factors among treatment-seeking adolescents with obesity in Italy, Germany and Norway.
This retrospective, registry-based, cross-sectional cohort study included 2,327 (59% girls) 12-18 year-old adolescents with obesity from three tertiary care outpatient clinics in Europe, between 1999 and 2015. The prevalence of cardiometabolic risk factors was compared between clinics, and multivariate logistic regression models including gender, age, waist circumference and body mass index were used to assess the associations between population and cardiometabolic risk.
In total, 1,396 adolescents (60% girls) from Italy, 654 (58% girls) from Germany and 277 (51% girls) from Norway were included. The mean ± SD age was 15.2 ± 1.6 years, body mass index 38.8 ± 6.5 kg/m and body mass index standard deviation score 3.21 ± 0.43. The prevalence of elevated nonhigh-density lipoprotein-cholesterol in Norway, Germany and Italy was 60%, 54% and 45%, while the prevalence of high systolic or diastolic blood pressure (≥130 or ≥85 mmHg) were 15%, 46% and 66%, respectively.
Cardiometabolic risk factors among treatment-seeking adolescents with obesity from Italy, Germany and Norway differed across the populations in this study, which might imply that preventive clinical work should reflect such differences.
本研究旨在比较意大利、德国和挪威寻求治疗的肥胖青少年的可改变心血管代谢风险因素。
本回顾性、基于登记的、横断面队列研究纳入了来自欧洲三个三级保健门诊的 2327 名（59%为女性）12-18 岁肥胖青少年，研究时间为 1999 年至 2015 年。比较了各诊所的心血管代谢风险因素的患病率，并采用包括性别、年龄、腰围和体重指数的多变量逻辑回归模型评估人群与心血管代谢风险之间的关联。
共纳入了来自意大利的 1396 名青少年（60%为女性）、德国的 654 名（58%为女性）和挪威的 277 名（51%为女性）。平均年龄±标准差为 15.2±1.6 岁，体重指数为 38.8±6.5kg/m2，体重指数标准差评分 3.21±0.43。挪威、德国和意大利的非高密度脂蛋白胆固醇升高的患病率分别为 60%、54%和 45%，而收缩压或舒张压升高（≥130 或≥85mmHg）的患病率分别为 15%、46%和 66%。
意大利、德国和挪威寻求治疗的肥胖青少年的心血管代谢风险因素在人群间存在差异，这可能意味着预防临床工作应反映出这些差异。
