Department of Emergency Surgery, University Hospital Foundation "Agostino Gemelli", Catholic University of the Sacred Heart, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(20):4668-4674.
To retrospectively compare the clinical outcomes of percutaneous cholecystostomy (PC) and cholecystectomy in patients with acute cholecystitis admitted to an urban University Hospital.
We studied 646 patients with acute cholecystitis. Ninety patients had placement of a PC at their index hospitalization, and 556 underwent cholecystectomy. Of the 90 patients with PC, 13 underwent subsequent elective cholecystectomy.
Overall, in-hospital mortality and postoperative complications were significantly higher in patients who received PC than in those who underwent cholecystectomy. In the ASA score 1-2 group, patients with PC were significantly older and had a longer postoperative stay while their mortality and morbidity were similar to patients who underwent cholecystectomy. In patients with ASA score of 3, PC and cholecystectomy did not differ significantly for demographic variables and clinical outcomes such as hospital stay, in-hospital mortality, postoperative complications and distribution of complications according to the classification of Clavien-Dildo. In mild, moderate, and severe cholecystitis, patients who underwent PC were significantly older than those who received cholecystectomy. In general, in mild, moderate and severe cholecystitis, the clinical outcomes did not differ significantly between patients who received PC and cholecystectomy. Morbidity was higher in patients with mild cholecystitis who underwent PC. Of the 77 patients dismissed from the hospital with drainage, 12 (15.6%) developed biliary complications and 5 needed substitutions of the drainage itself.
PC does not offer advantages compared to cholecystectomy in the treatment of acute cholecystitis. Its routine use is therefore questioned. There is need of an adequate, randomized study that compares PC and cholecystectomy in high-risk patients with moderate-severe cholecystitis.
回顾性比较在城市大学医院住院的急性胆囊炎患者行经皮胆囊造口术(PC)和胆囊切除术的临床结局。
我们研究了 646 例急性胆囊炎患者。90 例患者在首次住院时行 PC 置管,556 例行胆囊切除术。在 90 例行 PC 的患者中,有 13 例随后行择期胆囊切除术。
总体而言,接受 PC 的患者的住院死亡率和术后并发症明显高于行胆囊切除术的患者。在 ASA 评分 1-2 组中,接受 PC 的患者年龄明显较大,术后住院时间较长,但死亡率和发病率与行胆囊切除术的患者相似。在 ASA 评分 3 分的患者中,PC 和胆囊切除术在人口统计学变量和临床结局方面没有显著差异,如住院时间、住院死亡率、术后并发症以及根据 Clavien-Dildo 分类的并发症分布。在轻度、中度和重度胆囊炎中,接受 PC 的患者明显比接受胆囊切除术的患者年龄大。总体而言,在轻度、中度和重度胆囊炎中,接受 PC 和胆囊切除术的患者临床结局没有显著差异。接受 PC 的轻度胆囊炎患者的发病率较高。在 77 例带引流出院的患者中,有 12 例(15.6%)发生胆系并发症,5 例需要更换引流本身。
与胆囊切除术相比,PC 在治疗急性胆囊炎方面没有优势。因此,其常规应用受到质疑。需要进行一项充分的、随机的研究,比较 PC 和胆囊切除术在中重度胆囊炎的高危患者中的应用。