CD133、P57 和 HSF1 在脑膜瘤中的表达、相关性及其预后意义。
Expression, correlation and prognostic significance of CD133, P57 and HSF1 in meningioma.
机构信息
Tianjin Brain Trauma Center, Tianjin Huanhu Hospital, Tianjin, China.
出版信息
Eur Rev Med Pharmacol Sci. 2017 Oct;21(20):4600-4605.
OBJECTIVE
The present study investigated the expressions of CD133, P57 and HSF1 in meningioma so as to explore their protagonists in the prognosis of meningioma.
PATIENTS AND METHODS
The subjects in the present study included 57 cases of pathologically diagnosed patients with meningioma and 38 cases of non-meningioma patients. The immunofluorescence method was used to detect CD133, p57, and HSF1 expressions in the meningioma tissue. The reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting were used for expression studies in both the normal as well as meningioma tissues.
RESULTS
Immunofluorescence results showed high levels of expression of CD133, P57 and HSF1 in meningioma tissues. Further, the results of variance analyses confirmed that the expressions of CD133, P57, and HSF1 in meningioma tissues and normal brains tissue were significantly different (p < 0.01).
CONCLUSIONS
Expressions of CD133, p57, and HSF1 in meningioma are exceptionally high. The above observation could be exploited for the development of a novel treatment for a brain tumor and better clinical diagnosis as well.
目的
本研究旨在探讨 CD133、P57 和 HSF1 在脑膜瘤中的表达，以探索它们在脑膜瘤预后中的作用。
患者与方法
本研究共纳入 57 例经病理诊断的脑膜瘤患者和 38 例非脑膜瘤患者。采用免疫荧光法检测脑膜瘤组织中 CD133、p57 和 HSF1 的表达。采用逆转录-聚合酶链反应（RT-PCR）和 Western blot 法检测正常和脑膜瘤组织中的表达情况。
结果
免疫荧光结果显示脑膜瘤组织中 CD133、P57 和 HSF1 的表达水平较高。方差分析结果进一步证实，脑膜瘤组织和正常脑组织中 CD133、P57 和 HSF1 的表达存在显著差异（p<0.01）。
结论
脑膜瘤中 CD133、p57 和 HSF1 的表达水平异常升高。这一观察结果可能为脑肿瘤的新型治疗方法和更好的临床诊断提供依据。
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