Carmagnola Daniela, Tarce Mihai, Dellavia Claudia, Rimondini Lia, Varoni Elena M
Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi Milano, Milan - Italy.
Department of Oral Health Sciences, University of Leuven, Leuven - Belgium.
J Appl Biomater Funct Mater. 2017 Nov 10;15(4):e303-e312. doi: 10.5301/jabfm.5000389.
The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy.
A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies.
Evidence supports the importance of scaffold physical cues to promote periodontal regeneration, including scaffold multicompartmentalization and micropatterning. The in situ delivery of biological mediators and/or cell populations, both stem cells and already differentiated cells, has shown promising in vivo efficacy.
Porous scaffolds are pivotal for clot stabilization, wound compartmentalization, cell homing and cell nutrients delivery. Given the revolutionary introduction of rapid prototyping technique and cell-based therapies, the fabrication of custom-made scaffolds is not far from being achieved.
再生性牙周治疗的主要目标是完全恢复已丧失的牙周组织。本综述总结了支持基于支架和细胞的组织工程的最新证据，这些技术有望在下一代牙周再生治疗中发挥重要作用。
进行文献检索（PubMed数据库），以分析有关牙周再生、支架和基于细胞的技术的最新更新文章。
有证据支持支架物理线索对促进牙周再生的重要性，包括支架的多室化和微图案化。生物介质和/或细胞群体（包括干细胞和已分化细胞）的原位递送已显示出有前景的体内疗效。
多孔支架对于血凝块稳定、伤口分隔、细胞归巢和细胞营养物质递送至关重要。鉴于快速成型技术和基于细胞的疗法的革命性引入，定制支架的制造已指日可待。
