Li Zheng, Yang Bo, Weng Xisheng, Tse Gary, Chan Matthew T V, Wu William Ka Kei
Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
Cell Prolif. 2018 Feb;51(1). doi: 10.1111/cpr.12405. Epub 2017 Nov 12.
Osteonecrosis of the femoral head (ONFH) is one of the most common orthopaedic diseases. The exact pathogenic mechanism of ONFH is still unknown. MicroRNAs (miRNAs) are a class of non-coding RNAs that negatively modulate gene expression at post-transcriptional level. An increasing number of studies have shown that miRNAs play crucial roles in different physiological processes, including development, cell proliferation, differentiation and metabolism. Recently, multiple studies demonstrated that miRNAs are involved in the pathogenesis of ONFH. In this review, we summarize dysregulated miRNAs and their functions in ONFH. Furthermore, we discuss their potential clinical applications for diagnosis and treatment of ONFH.
股骨头坏死（ONFH）是最常见的骨科疾病之一。ONFH的确切致病机制尚不清楚。微小RNA（miRNA）是一类非编码RNA，在转录后水平上对基因表达进行负调控。越来越多的研究表明，miRNA在包括发育、细胞增殖、分化和代谢在内的不同生理过程中发挥着关键作用。最近，多项研究表明miRNA参与了ONFH的发病机制。在这篇综述中，我们总结了ONFH中失调的miRNA及其功能。此外，我们还讨论了它们在ONFH诊断和治疗中的潜在临床应用。
