Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.
Spring Grove Laboratories, 375 Thomas More Parkway, Suite 112, Crestview Hills, KY, 41017, USA.
Lipids Health Dis. 2017 Nov 13;16(1):214. doi: 10.1186/s12944-017-0608-1.
Obesity is considered problematic not only as a major cause of diabetes, hypertension, and dyslipidemia, but also as a risk of intractable dermatosis; however influence of obesity on skin function has not been clarified. To clarify the mechanism of obesity-associated skin disorders, we aimed to characterize the skin function of subjects with obesity, and identify possible influencing factors.
Complex analyses including instrumental measurement, biochemical and lipidomics were performed for facial skin and physical evaluation in 93 Caucasian women with obesity (OB) and non-obesity (NOB).
In OB, imbalance in metabolism of carbohydrate and lipid, autonomic nerve activity, and secreted factors were confirmed. In the skin properties in OB, surface roughness was higher by 70%, the water content was lower by 12%, and changes in the lipid profile of stratum corneum ceramide were observed; in particular, a 7% reduction of [NP]-type ceramide, compared with NOB. Moreover, significant redness accompanied by a 34% increase in skin blood flow was observed in OB. Correlation analysis elucidated that the water content was strongly correlated with local skin indices, such as the ceramide composition, redness, blood flow, and TNFα in the stratum corneum, whereas roughness was correlated with the systemic indices, such as serum insulin, leptin, and IL-6.
Characteristics of obesity-associated skin were (A) reduction of the barrier and moisturizing function accompanied by intercellular lipid imbalance, (B) increased redness accompanied by hemodynamic changes, and (C) surface roughness. It was suggested that each symptom is due to different causes in local and/or systemic physiological impairment related to the autonomic nerve-vascular system, inflammation and insulin resistance.
肥胖不仅被认为是糖尿病、高血压和血脂异常的主要病因，还被认为是难治性皮肤病的危险因素；然而，肥胖对皮肤功能的影响尚不清楚。为了阐明与肥胖相关的皮肤疾病的机制，我们旨在描述肥胖患者的皮肤功能，并确定可能的影响因素。
对 93 名白种肥胖女性（OB）和非肥胖女性（NOB）的面部皮肤进行了仪器测量、生化和脂质组学等复杂分析。
在 OB 中，证实了碳水化合物和脂质代谢、自主神经活动和分泌因子的失衡。在 OB 的皮肤特性中，表面粗糙度增加了 70%，水分含量降低了 12%，并且观察到角质层神经酰胺的脂质谱发生变化；特别是与 NOB 相比，[NP]-型神经酰胺减少了 7%。此外，在 OB 中观察到明显的发红，同时皮肤血流量增加了 34%。相关分析表明，水分含量与局部皮肤指数（如角质层神经酰胺组成、发红、血流和 TNFα）强烈相关，而粗糙度与血清胰岛素、瘦素和 IL-6 等系统性指数相关。
肥胖相关皮肤的特征是（A）屏障和保湿功能降低，细胞间脂质失衡，（B）发红增加伴有血液动力学变化，和（C）表面粗糙度。这表明每种症状都是由于局部和/或与自主神经血管系统、炎症和胰岛素抵抗相关的全身生理损伤引起的不同原因引起的。
