Nomura T, Yoshida-Amano Y, Yoshida K, Fujii A, Tanahashi M, Sugiyama Y, Iwata K, Murase T
Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga, Tochigi, 321-3497 Japan.
Health Beauty Products, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo, 131-8501 Japan.
Int J Cosmet Sci. 2017 Jun;39(3):275-283. doi: 10.1111/ics.12373. Epub 2016 Nov 2.
Several studies have shown that a deterioration of skin properties, an impaired cutaneous microcirculatory function and an imbalance of autonomic nervous activity are observed in smokers and in patients with diabetes mellitus or Raynaud's phenomenon. These observations suggest that skin properties are associated with cutaneous microcirculatory function and autonomic nervous activity in pathological conditions. However, there is no published evidence to support the concept that these two functions have any relationship with skin properties even in healthy subjects. To investigate the hypothesis that these properties are related, we conducted a survey of healthy adult subjects to investigate the relationships between cutaneous microcirculatory function and autonomic nervous activity and skin properties.
The hydration of the stratum corneum and transepidermal water loss (TEWL) were investigated as skin properties, and the responsiveness of skin blood flow (SkBF) to local warming was examined as an index of cutaneous microcirculatory function in 19 healthy adult male subjects. Electrocardiograms were monitored for 24 h and heart rate variability was analysed considering low-frequency power (LF: 0.04-0.15 Hz), high-frequency power (HF: 0.15-0.40 Hz) and a ratio of low- to high-frequency power (LF/HF) as indices of autonomic nervous activity; HF is an index of parasympathetic activity, whereas LF/HF is an index of sympathovagal balance. The relationships between those indices were then analysed.
A moderate negative correlation was found between TEWL and the relative maximum rate of increases in the responsiveness of SkBF on local warming. A moderate positive and a moderate negative correlation were observed between TEWL and LF/HF or HF, respectively. Moreover, a moderate negative and a moderate positive correlation were shown between the responsiveness of SkBF and LF/HF or HF, respectively. The hydration of the stratum corneum showed no correlations with any indices of microcirculation or autonomic nervous activity.
These results indicate that skin barrier function, cutaneous microcirculatory function and autonomic nervous activity are mutually associated in healthy adults.
多项研究表明，吸烟者、糖尿病患者或雷诺现象患者存在皮肤特性恶化、皮肤微循环功能受损以及自主神经活动失衡的情况。这些观察结果表明，在病理状态下，皮肤特性与皮肤微循环功能和自主神经活动相关。然而，尚无已发表的证据支持即使在健康受试者中这两种功能与皮肤特性存在任何关系的概念。为了研究这些特性相关的假设，我们对健康成年受试者进行了一项调查，以研究皮肤微循环功能、自主神经活动与皮肤特性之间的关系。
在19名健康成年男性受试者中，研究角质层水合作用和经表皮水分流失（TEWL）作为皮肤特性，并检测皮肤血流（SkBF）对局部升温的反应性作为皮肤微循环功能指标。监测心电图24小时，并分析心率变异性，将低频功率（LF：0.04 - 0.15Hz）、高频功率（HF：0.15 - 0.40Hz）以及低频与高频功率之比（LF/HF）作为自主神经活动指标；HF是副交感神经活动指标，而LF/HF是交感神经与迷走神经平衡指标。然后分析这些指标之间的关系。
TEWL与局部升温时SkBF反应性的相对最大增加率之间存在中度负相关。TEWL与LF/HF或HF之间分别观察到中度正相关和中度负相关。此外，SkBF反应性与LF/HF或HF之间分别显示出中度负相关和中度正相关。角质层水合作用与任何微循环或自主神经活动指标均无相关性。
这些结果表明，在健康成年人中，皮肤屏障功能、皮肤微循环功能和自主神经活动相互关联。
