Li Hong-Hua, Wang Bing, Shan Ling, Wang Cheng-Xin, Jia Fei-Yong
Department of Developmental and Behavioral Pediatrics, First Hospital of Jilin University, Changchun 130021, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Nov;19(11):1165-1168. doi: 10.7499/j.issn.1008-8830.2017.11.008.
To examine serum 25-hydroxyvitamin D levels in children with tic disorders (TD) and to explore the relationship between vitamin D level and TD.
One hundred and thirty-two children who were diagnosed with TD between November 2016 and May 2017 were enrolled as the TD group, including 8 cases of Tourette syndrome, 32 cases of chronic TD, and 92 cases of transient TD. One hundred and forty-four healthy children served as the control group. Peripheral venous blood samples were collected from each child. Serum levels of 25-hydroxyvitamin D were measured using HPLC-MS/MS. The categories of vitamin D status based on serum 25-hydroxyvitamin D level included: normal (>30 ng/mL), insufficiency (10-30 ng/mL) and deficiency (<10 ng/mL).
Mean serum level of 25-hydroxyvitamin D in the TD group was significantly lower than that in the control group (P<0.01). The rate of vitamin D insufficiency or deficiency in the TD group was significantly higher than in the control group (P<0.01). Mean serum level of 25-hydroxyvitamin D in the transient tic group was higher than in the TS group (P<0.05).
Vitamin D insufficiency or deficiency might be associated with the development of TD, and the level of serum 25-hydroxyvitamin D might be related to the classification of TD.
检测抽动障碍（TD）患儿血清25-羟维生素D水平，探讨维生素D水平与TD的关系。
选取2016年11月至2017年5月期间确诊为TD的132例患儿作为TD组，其中包括8例抽动秽语综合征、32例慢性TD和92例短暂性TD。选取144例健康儿童作为对照组。采集每个儿童的外周静脉血样本。采用高效液相色谱-串联质谱法测定血清25-羟维生素D水平。根据血清25-羟维生素D水平划分的维生素D状态类别包括：正常（>30 ng/mL）、不足（10 - 30 ng/mL）和缺乏（<10 ng/mL）。
TD组血清25-羟维生素D的平均水平显著低于对照组（P<0.01）。TD组维生素D不足或缺乏的发生率显著高于对照组（P<0.01）。短暂性抽动组血清25-羟维生素D的平均水平高于抽动秽语综合征组（P<0.05）。
维生素D不足或缺乏可能与TD的发生有关，血清25-羟维生素D水平可能与TD的分类有关。
