Fragomeni Simona Maria, Sciallis Andrew, Jeruss Jacqueline S
Division of Gynecologic Oncology, Multidisciplinary Breast Center, Catholic University of the Sacred Heart of Rome, L.go Agostino Gemelli 8, 00168 Rome, Italy.
Division of Anatomic Pathology, Department of Pathology, University of Michigan, Ann Arbor, MI 48105, USA.
Surg Oncol Clin N Am. 2018 Jan;27(1):95-120. doi: 10.1016/j.soc.2017.08.005.
In the era of personalized medicine, there has been significant progress regarding the molecular analysis of breast cancer subtypes. Research efforts have focused on how classification of subtypes could provide information on prognosis and influence treatment planning. Although much is known about the impact of different molecular subtypes on disease-specific survival, more recent studies have investigated the role of the different molecular subtypes on local-regional recurrence. This is an area of active study, and in recent years there has been significant progress. This article describes outcomes among disease subtypes to aid in optimal surgical decision-making to improve local-regional control.
在个性化医疗时代，乳腺癌亚型的分子分析取得了重大进展。研究工作聚焦于亚型分类如何能提供预后信息并影响治疗方案的制定。尽管对于不同分子亚型对疾病特异性生存的影响已有很多了解，但最近的研究探讨了不同分子亚型在局部区域复发中的作用。这是一个活跃的研究领域，近年来已取得显著进展。本文描述了不同疾病亚型的治疗结果，以辅助做出最佳手术决策，从而改善局部区域控制。
