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口服耐受的形成与维持。

Oral Tolerance Development and Maintenance.

作者信息

Wambre Erik, Jeong David

机构信息

Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.

Virginia Mason Medical Center, 1201 Terry Avenue, Seattle, WA 98101, USA.

出版信息

Immunol Allergy Clin North Am. 2018 Feb;38(1):27-37. doi: 10.1016/j.iac.2017.09.003. Epub 2017 Oct 26.

DOI:10.1016/j.iac.2017.09.003
PMID:29132672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5776674/
Abstract

The gastrointestinal tract has an abundant mucosal immune system to develop and maintain oral tolerance. The oral route of administration takes advantage of the unique set of immune cells and pathways involved in the induction of oral tolerance. Food allergy results from a loss of oral tolerance toward ingested antigens. Oral immunotherapy is thought to initiate desensitization through interaction of an allergen with mucosal dendritic cells that initiate downstream immune system modulation through regulatory T cells and effector T cells.

摘要

胃肠道拥有丰富的黏膜免疫系统来建立和维持口服耐受性。口服给药途径利用了参与诱导口服耐受性的独特免疫细胞和途径。食物过敏是由于对摄入抗原的口服耐受性丧失所致。口服免疫疗法被认为是通过变应原与黏膜树突状细胞的相互作用启动脱敏过程，而黏膜树突状细胞通过调节性T细胞和效应T细胞启动下游免疫系统调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a4/5776674/716d6d090393/nihms917466f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a4/5776674/716d6d090393/nihms917466f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a4/5776674/716d6d090393/nihms917466f1.jpg

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A phenotypically and functionally distinct human T2 cell subpopulation is associated with allergic disorders.一种表型和功能上不同的人类T2细胞亚群与过敏性疾病有关。
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Tissue adaptation: Implications for gut immunity and tolerance.组织适应性：对肠道免疫和耐受性的影响。
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Role of Regulatory Cells in Oral Tolerance.调节性细胞在口服耐受中的作用。
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Diversity of complementary diet and early food allergy risk.辅食多样性与早期食物过敏风险
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Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model.在易患过敏的棕色挪威大鼠模型中，在哺乳和断奶期间喂食二十二碳六烯酸和花生四烯酸，通过有益地调节肠道细胞因子和免疫球蛋白水平，有助于口腔耐受性的发展。
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Immunotherapeutic potential of collagen V oral administration in mBSA/CFA-induced arthritis.口服胶原 V 在 mBSA/CFA 诱导的关节炎中的免疫治疗潜力。
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