口服耐受的形成与维持。
Oral Tolerance Development and Maintenance.
作者信息
Wambre Erik, Jeong David
机构信息
Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.
Virginia Mason Medical Center, 1201 Terry Avenue, Seattle, WA 98101, USA.
出版信息
Immunol Allergy Clin North Am. 2018 Feb;38(1):27-37. doi: 10.1016/j.iac.2017.09.003. Epub 2017 Oct 26.
Abstract
The gastrointestinal tract has an abundant mucosal immune system to develop and maintain oral tolerance. The oral route of administration takes advantage of the unique set of immune cells and pathways involved in the induction of oral tolerance. Food allergy results from a loss of oral tolerance toward ingested antigens. Oral immunotherapy is thought to initiate desensitization through interaction of an allergen with mucosal dendritic cells that initiate downstream immune system modulation through regulatory T cells and effector T cells.
摘要
胃肠道拥有丰富的黏膜免疫系统来建立和维持口服耐受性。口服给药途径利用了参与诱导口服耐受性的独特免疫细胞和途径。食物过敏是由于对摄入抗原的口服耐受性丧失所致。口服免疫疗法被认为是通过变应原与黏膜树突状细胞的相互作用启动脱敏过程，而黏膜树突状细胞通过调节性T细胞和效应T细胞启动下游免疫系统调节。
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