Loh Wenyin, Tang Mimi
Allergy and Immune Disorders, Murdoch Children's Research Institute, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia; Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Bukit Timah Road, Singapore, S558076, Singapore.
Allergy and Immune Disorders, Murdoch Children's Research Institute, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia; Department of Paediatrics, University of Melbourne, The Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia; Allergy and Immunology, The Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia.
Immunol Allergy Clin North Am. 2018 Feb;38(1):89-101. doi: 10.1016/j.iac.2017.09.008. Epub 2017 Oct 26.
Finding an effective curative treatment for food allergy is a research priority. Although oral immunotherapy (OIT) is effective at inducing desensitization, the temporary nature of this effect and high rates of adverse reactions have highlighted a need for novel strategies to improve tolerance induction and safety. One such strategy is the use of an adjuvant together with food immunotherapy to either suppress allergic reactions and/or modulate the underlying allergic immune response. In particular, the use of bacterial adjuvants seems to be a promising means of enhancing OIT-induced sustained unresponsiveness and warrants further investigation.
找到一种有效的食物过敏治疗方法是研究的重点。尽管口服免疫疗法（OIT）在诱导脱敏方面有效，但这种效果的暂时性和高不良反应率凸显了需要新的策略来提高耐受性诱导和安全性。一种这样的策略是将佐剂与食物免疫疗法一起使用，以抑制过敏反应和/或调节潜在的过敏免疫反应。特别是，使用细菌佐剂似乎是增强OIT诱导的持续无反应性的一种有前景的方法，值得进一步研究。
