出生、成年和死亡：长链非编码 RNA 的有趣生命历程。
Birth, coming of age and death: The intriguing life of long noncoding RNAs.
机构信息
Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, RIKEN Yokohama, Japan.
出版信息
Semin Cell Dev Biol. 2018 Jul;79:143-152. doi: 10.1016/j.semcdb.2017.11.012. Epub 2017 Nov 20.
Mammalian genomes are pervasively transcribed, with long noncoding RNAs being the most abundant fraction. Recent studies have highlighted the central role played by these transcripts in several physiological and pathological processes. Despite several metabolic features shared between coding and noncoding transcripts, these two classes of RNAs exhibit multiple differences regarding their biogenesis and processing. Here we review such distinctions, focusing on the unique features of specific long noncoding RNAs.
哺乳动物基因组广泛转录，其中长非编码 RNA 是最丰富的部分。最近的研究强调了这些转录本在几种生理和病理过程中所起的核心作用。尽管编码和非编码转录本具有一些共同的代谢特征，但这两类 RNA 在其生物发生和加工方面表现出多种差异。本文综述了这些差异，重点介绍了特定长非编码 RNA 的独特特征。
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