Department of Environmental and Occupational Health, University of South Florida, Tampa, Florida, USA.
Department of Community and Family Health, University of South Florida, Tampa, Florida, USA.
BMJ Open. 2017 Nov 12;7(11):e017161. doi: 10.1136/bmjopen-2017-017161.
To assess birth outcomes in primiparous women with diagnosis of non-asthmatic atopy (NAA). Researchers hypothesised that women with NAA would have reduced the risk of adverse birth outcomes compared with women without NAA. NAA is defined as having allergic rhinitis and/or atopic dermatitis.
Women were mostly treated in primary care settings in South Carolina, USA.
This is a retrospective cohort study in which participants were identified using a Medicaid database. Participants were primiparous women aged 19 to 25. Births occurring between 2004 and 2014 were identified using the South Carolina's Vital Statistics (VS) records of live births. Incomplete records (ie, information on plural birth, gestational age at birth or birth weight missing), plural births or infants born before completing 24 weeks of gestation were excluded. This provided 65 650 complete maternal-infant dyads, representing 97.6% of the maternal records and 96.9% of the VS records. Women previously diagnosed with NAA were frequency matched 1:4 to non-atopic controls for a total of 9965 maternal-infant dyads used in the statistical analysis.
Low birth weight, small for gestational age and preterm birth.
Linear tests for trend were statistically significant (p<0.001), indicating that NAA was associated with improved birth weight and gestational age at birth. After controlling for potential confounders, mothers with NAA had equal risk for each outcome when compared with mothers with no diagnosis of NAA.
A diagnosis of NAA among women living in the southeastern region of the USA does not reduce the risk of adverse birth outcomes nor does it elevate the risk of same. Additional studies with more rigorous designs are warranted to confirm the findings in this study.
评估初产妇中非哮喘特应性（NAA）诊断的分娩结局。研究人员假设，与无 NAA 的女性相比，患有 NAA 的女性不良分娩结局的风险降低。NAA 的定义为患有过敏性鼻炎和/或特应性皮炎。
这些女性主要在美国南卡罗来纳州的初级保健环境中接受治疗。
这是一项回顾性队列研究，参与者是使用医疗补助数据库确定的。参与者为年龄在 19 至 25 岁的初产妇。使用南卡罗来纳州生命统计（VS）活产记录识别 2004 年至 2014 年期间发生的分娩。排除不完整记录（即，多胎出生、出生时的胎龄或出生体重信息缺失）、多胎分娩或出生前未完成 24 周妊娠的婴儿。这提供了 65650 对完整的母婴对，代表了 97.6%的产妇记录和 96.9%的 VS 记录。先前被诊断患有 NAA 的女性按频率与非特应性对照组 1:4 匹配，共 9965 对母婴对用于统计分析。
低出生体重、小于胎龄儿和早产。
线性趋势检验具有统计学意义（p<0.001），表明 NAA 与出生体重和出生时的胎龄增加有关。在控制潜在混杂因素后，与无 NAA 诊断的母亲相比，患有 NAA 的母亲在每种结局发生的风险方面没有差异。
在美国东南部地区生活的女性中诊断出 NAA 不会降低不良分娩结局的风险，也不会增加相同的风险。需要进行更多设计严格的研究来证实本研究的结果。
