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Gray matter asymmetries in aging and neurodegeneration: A review and meta-analysis.大脑灰质的衰老和神经退行性变的不对称性:综述和荟萃分析。
Hum Brain Mapp. 2017 Dec;38(12):5890-5904. doi: 10.1002/hbm.23772. Epub 2017 Aug 30.
2
Dexmedetomidine Prevents Lipopolysaccharide-Induced MicroRNA Expression in the Adult Rat Brain.右美托咪定可预防脂多糖诱导的成年大鼠大脑中的微小RNA表达。
Int J Mol Sci. 2017 Aug 23;18(9):1830. doi: 10.3390/ijms18091830.
3
Blood Pressure Targets in the Hypertensive Elderly.高血压老年人的血压目标。
Chin Med J (Engl). 2017 Aug 20;130(16):1968-1972. doi: 10.4103/0366-6999.211885.
4
Pharmacologic Considerations of Anesthetic Agents in Geriatric Patients.老年患者麻醉药物的药理学考量
Anesthesiol Clin. 2017 Jun;35(2):259-271. doi: 10.1016/j.anclin.2017.01.011. Epub 2017 Mar 30.
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Anesthesia, brain changes, and behavior: Insights from neural systems biology.麻醉、大脑变化和行为:神经系统生物学的新见解。
Prog Neurobiol. 2017 Jun;153:121-160. doi: 10.1016/j.pneurobio.2017.01.005. Epub 2017 Feb 8.
6
Dexmedetomidine enhances human lung fluid clearance through improving alveolar sodium transport.右美托咪定通过改善肺泡钠转运增强人肺液体清除能力。
Fundam Clin Pharmacol. 2017 Aug;31(4):429-437. doi: 10.1111/fcp.12278. Epub 2017 Mar 1.
7
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Medicine (Baltimore). 2016 Oct;95(42):e5056. doi: 10.1097/MD.0000000000005056.
9
Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats.右美托咪定对老年大鼠全身炎症后认知功能障碍发生的预防作用。
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10
Dexmedetomidine protected COPD-induced lung injury by regulating miRNA-146a.右美托咪定通过调节miRNA-146a保护慢性阻塞性肺疾病诱导的肺损伤。
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中国老年患者麻醉相关发病率和死亡率:现状和趋势。

Geriatric Anesthesia-related Morbidity and Mortality in China: Current Status and Trend.

机构信息

Department of Anesthesiology and Operating Theatre, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Chin Med J (Engl). 2017 Nov 20;130(22):2738-2749. doi: 10.4103/0366-6999.218006.

DOI:10.4103/0366-6999.218006
PMID:29133765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5695062/
Abstract

OBJECTIVE

The population of elderly patients and the amount of geriatric anesthesia have been growing rapidly in China. Thus, understanding the morbidity and mortality associated with geriatric anesthesia in China is critical to the improvement of anesthesia quality and outcome. The aim of the review was to discuss the geriatric anesthesia-related morbidity and mortality in China, as well as to point out the future trend.

DATA SOURCES

Articles in this review were all searched from Wanfang, China National Knowledge Infrastructure (CNKI), VIP, PubMed, and Web of Science databases, based on the reports originated in China from January 2011 to December 2016.

STUDY SELECTION

A total of 57 studies were selected for further study, including 12 retrospective studies, 35 prospective studies, 3 meta-analyses, 4 reviews, 1 viewpoint, and 2 case reports. Of the total studies, 42 studies were in Chinese while 15 were in English.

RESULTS

The mortality and morbidity associated with geriatric anesthesia in China are not yet completely reported. Some factors have been recognized, while some are yet to be identified and confirmed. Several studies addressed postoperative cognitive dysfunction and postoperative delirium, whereas only a few studies can be found on renal complications. Thus, a nationwide registry is essential for geriatric anesthesia-associated adverse outcomes. The mortality associated with geriatric anesthesia in China should be reported promptly. In the future, the perspective of geriatric anesthesia needs to be expanded into perioperative geriatric medicine to improve the perioperative management strategy based on the postoperative outcome-directed concept transformation.

CONCLUSIONS

Anesthesiologists should evaluate the physiological and medical status and focus on the prevention of potential complications in the perioperative setting with the goal to enhance elderly patients' long-term well-being and survival quality.

摘要

目的

中国老年患者人群和老年麻醉数量增长迅速。因此,了解中国老年麻醉相关发病率和死亡率对于提高麻醉质量和结果至关重要。本综述的目的是讨论中国老年麻醉相关发病率和死亡率,并指出未来的趋势。

资料来源

本综述中的文章均根据 2011 年 1 月至 2016 年 12 月源自中国的报告,从万方、中国知网(CNKI)、维普、PubMed 和 Web of Science 数据库中检索。

研究选择

共选择了 57 项研究进行进一步研究,包括 12 项回顾性研究、35 项前瞻性研究、3 项荟萃分析、4 项综述、1 项观点和 2 项病例报告。在总共的研究中,42 项是中文的,15 项是英文的。

结果

中国老年麻醉相关发病率和死亡率尚未完全报告。一些因素已经得到承认,而有些因素尚未确定和确认。一些研究涉及术后认知功能障碍和术后谵妄,而只有少数研究涉及肾脏并发症。因此,建立一个全国性的登记处对于老年麻醉相关不良结局至关重要。中国老年麻醉相关死亡率应及时报告。未来,老年麻醉的观点需要扩展到围手术期老年医学,以根据术后结果导向的概念转变,改善围手术期管理策略。

结论

麻醉师应在围手术期评估生理和医学状态,并专注于预防潜在并发症,以提高老年患者的长期健康和生存质量。