Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK.
Department of Academic Cardiology, University of Hull, Hull, UK.
Sci Rep. 2017 Nov 13;7(1):15366. doi: 10.1038/s41598-017-15402-9.
Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementation on BTM in T2DM and particularly in men is unclear. We performed an analysis of a randomized double blind parallel study of 200 men with T2DM treated with soy, either with or without isoflavones. Outcome measures were type I collagen crosslinked beta C-telopeptide (βCTX), and type 1 procollagen-N-propeptide (P1NP). The men, with a total testosterone <12 nmol/L, were treated with 15 g soy protein containing 66 mg of isoflavones (SPI) or 15 g soy protein alone without isoflavones (SP) daily for three months. There was a 15% reduction in βCTX after three months of SPI compared to SP supplementation. There was no significant difference in P1NP with either SPI or SP supplementation. There was a significant linear correlation between the reduction in βCTX in the SPI group with the reduction in HbA1c (r = 0.42; p = 0.04) and HOMA-IR (r = 0.54; p = 0.02). Our study indicates that there was a significant reduction in bone resorption following 3 months of SPI supplementation that correlated with an improvement of glycemic control in men with T2DM.
2 型糖尿病（T2DM）与骨折风险增加有关。大豆补充剂已被证明对绝经后妇女的骨转换标志物（BTM）有有益的影响。然而，大豆补充剂对 T2DM 患者，尤其是男性的 BTM 的影响尚不清楚。我们对 200 名 T2DM 男性进行了一项随机双盲平行研究的分析，这些男性接受了大豆补充剂治疗，其中一些含有异黄酮，另一些则不含。观察指标为 I 型胶原交联β C-端肽（βCTX）和 I 型前胶原 N-端肽（P1NP）。总睾酮<12 nmol/L 的男性每天接受 15 g 含有 66 mg 异黄酮的大豆蛋白（SPI）或 15 g 不含异黄酮的大豆蛋白（SP）治疗，持续三个月。与 SP 补充相比，SPI 补充三个月后βCTX 降低了 15%。SPI 或 SP 补充对 P1NP 没有显著影响。SPI 组中βCTX 的降低与 HbA1c（r=0.42；p=0.04）和 HOMA-IR（r=0.54；p=0.02）的降低呈显著线性相关。我们的研究表明，在接受 SPI 补充 3 个月后，骨吸收明显减少，这与 T2DM 男性血糖控制的改善相关。
