Sathyapalan T, Aye M, Rigby A S, Thatcher N J, Dargham S R, Kilpatrick E S, Atkin S L
Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK.
Department of Academic Cardiology, University of Hull, UK.
Nutr Metab Cardiovasc Dis. 2018 Jul;28(7):691-697. doi: 10.1016/j.numecd.2018.03.007. Epub 2018 Apr 10.
Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers.
The expected 10-year risk of cardiovascular disease and mortality were calculated as a secondary endpoint from a double blind randomised parallel study involving 200 women (mean age 55 years, Caucasian, Hull, UK, 2012) in the early menopause who were randomised to 15 g soy protein with 66 mg isoflavone (SPI) or 15 g soy protein alone (depleted of all isoflavones; SP) given as a snack bar between meals daily for 6 months. Age, diabetes, smoking, blood pressure and lipid profiles were used to calculate CVR using the Framingham CVR engine.
SPI treatment resulted in a significant reduction in the metabolic parameters and systolic blood pressure compared to SP (p < 0.01). There were no changes in fasting lipid profile and diastolic blood pressure with either treatment. At 6 months, changes in these parameters with SPI treatment were reflected in a calculated 27% (p < 0.01) reduction in 10 year coronary heart disease risk, a 37% (p < 0.01) reduction in myocardial infarction risk, a 24% (p < 0.04) reduction in cardiovascular disease and 42% (p < 0.02) reduction in cardiovascular disease death risk.
Supplementation with soy protein with isoflavones for 6 months significantly improved CVR markers and calculated CVR at 6 months during early menopause compared to soy protein without isoflavones.
ISRCTN34051237.
激素替代疗法可能对绝经后女性的心血管疾病风险（CVR）有益。大豆异黄酮可能作为选择性雌激素受体调节剂发挥作用。本研究的目的是评估大豆异黄酮是否对CVR标志物有影响。
作为次要终点，从一项双盲随机平行研究中计算出预期的10年心血管疾病风险和死亡率，该研究涉及200名处于绝经早期的女性（平均年龄55岁，白种人，英国赫尔，2012年），她们被随机分为两组，一组每天在两餐之间食用含有66毫克异黄酮的15克大豆蛋白（SPI），另一组每天食用仅含15克大豆蛋白（不含所有异黄酮；SP）的零食棒，持续6个月。使用弗明汉心血管疾病风险评估工具，根据年龄、糖尿病、吸烟情况、血压和血脂谱来计算CVR。
与SP相比，SPI治疗导致代谢参数和收缩压显著降低（p < 0.01）。两种治疗方法对空腹血脂谱和舒张压均无影响。在6个月时，SPI治疗后这些参数的变化反映在计算得出的10年冠心病风险降低27%（p < 0.01）、心肌梗死风险降低37%（p < 0.01）、心血管疾病风险降低24%（p < 0.04）以及心血管疾病死亡风险降低42%（p < 0.02）。
与不含异黄酮的大豆蛋白相比，补充含异黄酮的大豆蛋白6个月可显著改善绝经早期6个月时的CVR标志物并降低计算得出的CVR。
ISRCTN34051237
