Verma Rajeev Kumar, Keller Desislava, Grunt Sebastian, Bigi Sandra, Weisstanner Christian, Wiest Roland, Gralla Jan, Hutter Damian, Wagner Bendicht
University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland.
Institute of Radiology and Neuroradiology, Tiefenau Hospital, Division Stadt, Inselgroup, Bern, Switzerland.
Sci Rep. 2017 Nov 13;7(1):15471. doi: 10.1038/s41598-017-15591-3.
Purpose of this study was to investigate a potential correlation between the pattern of cerebral veins (CV) on susceptibility-weighted imaging (SWI) and blood oxygen saturation, as well as preoperative brain injury, in neonates with transposition of the great arteries (TGA). Eleven neonates with TGA underwent MRI preoperatively, including SWI, T1- and T2-weighted scans. Images were retrospectively evaluated and appearance of CV was graded from 0 (normal appearance) to 3 (severe prominent appearance). White matter injuries (WMI) and strokes were analysed. Results were correlated with preductal arterial oxygen saturation. As findings one subject showed a normal CV appearance (grade 0) whereas 10 showed pathological prominent CV (grades 1-3); median 2. Mean oxygen saturation ranged between 67.5% and 89.0% (median 81.0%). CV grade and mean oxygen saturation correlated significantly (p = 0.011). WMI were absent in 5 cases, mild in 4, and moderate in 2 cases. We conclude, that SWI has the potential to be used to estimate the current hypoxic burden on brain tissue in TGA newborns by assessing the prominence of the CV.
本研究的目的是调查大动脉转位（TGA）新生儿的磁敏感加权成像（SWI）上脑静脉（CV）的形态与血氧饱和度以及术前脑损伤之间的潜在相关性。11例TGA新生儿术前接受了MRI检查，包括SWI、T1加权和T2加权扫描。对图像进行回顾性评估，并将CV的外观从0级（正常外观）到3级（严重突出外观）进行分级。分析了白质损伤（WMI）和中风情况。结果与导管前动脉血氧饱和度相关。结果显示，1例受试者CV外观正常（0级），而10例显示病理性突出的CV（1-3级）；中位数为2级。平均血氧饱和度在67.5%至89.0%之间（中位数为81.0%）。CV分级与平均血氧饱和度显著相关（p = 0.011）。5例无WMI，4例轻度，2例中度。我们得出结论，SWI有潜力通过评估CV的突出程度来估计TGA新生儿脑组织当前的缺氧负担。
