Snyder A K, Singh S P
Department of Medicine, Chicago Medical School, IL.
Metabolism. 1989 Feb;38(2):149-52. doi: 10.1016/0026-0495(89)90254-0.
Glucose turnover was measured in term pregnant rats fed ethanol (30% of caloric intake) throughout gestation. Ethanol ingestion significantly reduced maternal weight gain and term fetal body weight when compared to pair-fed or ad libitum-fed controls. At term the blood glucose level and 6-3H-glucose turnover were reduced when compared to either control group. The rate of gluconeogenic recycling, indicated by the difference between 6-3H and 6-14C-glucose turnover determinations, was reduced by ethanol ingestion to half that of the control groups. Glucose turnover correlated with both conceptus weight and blood glucose level. Impaired maternal glucose homeostasis, including a reduced gluconeogenic response to the metabolic demands of late pregnancy, may thus contribute to the effects of ethanol on intrauterine growth.
在整个妊娠期给足月妊娠大鼠喂食乙醇（热量摄入的30%），并测量其葡萄糖周转率。与配对喂食或自由进食的对照组相比，摄入乙醇显著降低了母体体重增加和足月胎儿体重。足月时，与任一对照组相比，血糖水平和6-3H-葡萄糖周转率均降低。通过6-3H和6-14C-葡萄糖周转率测定之间的差异表明，乙醇摄入使糖异生循环率降低至对照组的一半。葡萄糖周转率与胎儿体重和血糖水平均相关。因此，母体葡萄糖稳态受损，包括对妊娠晚期代谢需求的糖异生反应降低，可能是乙醇对子宫内生长产生影响的原因。
