School of Psychology, Nanjing Normal University, Nanjing, China.
Rehabilitation Medicine Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Am J Addict. 2017 Dec;26(8):776-779. doi: 10.1111/ajad.12638. Epub 2017 Nov 14.
The study is to investigate if left or right dorsolateral prefrontal cortex is important in modulating the craving to drug related cues.
The present investigation examined different combinations between left/right and high/low frequency rTMS on cue induced craving to methamphetamine, with active sham rTMS on P3 region on a total of 50 subjects.
The results showed that either at left or right side, both high and low frequency rTMS are effective in decreasing the cue induced craving to methamphetamine.
In conclusion, bilateral frontal hemispheres are effective in modulating the cue induced craving to methamphetamine with rTMS.
TMS targeting prefrontal cortex is effective for craving modulation; however the mechanism is more than potentiation or depression of single brain region. (Am J Addict 2017;26:776-779).
本研究旨在探讨左、右背外侧前额叶皮层在调节与药物相关线索的渴求程度方面的作用。
本研究通过对 50 名受试者进行不同的左/右和高/低频率 rTMS 与 P3 区主动假 rTMS 相结合的实验，考察了左/右和高/低频率 rTMS 对甲基苯丙胺诱发的渴求的影响。
结果表明，左、右侧高频和低频 rTMS 均能有效降低甲基苯丙胺诱发的渴求。
总之，双侧额叶在调节甲基苯丙胺诱发的渴求方面是有效的。
针对前额叶皮层的 TMS 对渴求调节有效；然而，其机制不仅仅是单个脑区的增强或抑制。
