Ciroma F L, Ayo J O, Mohammed A, Akor-Dewu M B, Kana M A, Kase S N
Department of Human Physiology, Faculty of Medicine, Kaduna State University, Kaduna.
Niger J Physiol Sci. 2017 Jun 30;32(1):69-74.
Obesity is an energy imbalance condition, which is accompanied by metabolic and cardiovascular complications.Adiponectin, produced by adipocytes, is an important adipokine involved in carbohydrate and lipid metabolism. Adiponectinlevel is altered in obesity in various populations. In Nigeria, very few studies regarding adiponectin exist, and none, to thebest of our knowledge, investigated the relationship between adiponectin and lipid profile and obesity. Therefore, this studyaims to evaluate changes in adiponectin level and serum lipids with body mass index, and investigate the relationship betweenadiponectin, serum lipids and obesity in Nigerian adults. Anthropometric parameters and blood pressure were measured, and blood samples were collected for biochemical assessment after 12 hours fasting, in a total of 280 subjects, comprising of 186males and 94 females. Serum adiponectin level was evaluated by ELISA, while serum lipid profile was determined byenzymatic endpoint method. Quantitative data were analyzed for significant difference using ANOVA, and Pearson'scorrelation was used to evaluate relationships. Serum adiponectin level was significantly (P ˂ 0.05) highest within overweightmale subjects (1.6 ± 0.06 µg/ml), and lowest within normal male subjects (1.4 ± 0.03 µg/ml). The values for adiponectin concentrations were not significantly different in the female subjects. There was no association in serum lipids andadiponectin in both male (r = -0.035, P >0.05; r = -0.011, P >0.05; r = -0.053, P >0.05; r = -0.084, P >0.05) and female (r=0.061, P >0.05; r = 0.018, P>0.05; r = 0.057, P>0.05; r = -0.021, P >0.05) for LDL, HDL, TC and TRIG respectively. Lipidprofile was not different across BMI classes. There was no relationship between adiponectin and serum lipids in individualsin the study population of adult Nigerians.
肥胖是一种能量失衡状态，伴有代谢和心血管并发症。脂联素由脂肪细胞产生，是一种参与碳水化合物和脂质代谢的重要脂肪因子。在不同人群中，肥胖时脂联素水平会发生改变。在尼日利亚，关于脂联素的研究很少，据我们所知，没有研究调查脂联素与血脂谱及肥胖之间的关系。因此，本研究旨在评估脂联素水平和血脂随体重指数的变化，并调查尼日利亚成年人中脂联素、血脂与肥胖之间的关系。对总共280名受试者（包括186名男性和94名女性）测量了人体测量参数和血压，并在禁食12小时后采集血样进行生化评估。通过酶联免疫吸附测定法（ELISA）评估血清脂联素水平，而血脂谱则通过酶促终点法测定。使用方差分析（ANOVA）分析定量数据的显著差异，并使用皮尔逊相关性评估关系。血清脂联素水平在超重男性受试者中显著最高（P＜0.05）（1.6±0.06μg/ml），在正常男性受试者中最低（1.4±0.03μg/ml）。女性受试者中脂联素浓度值无显著差异。男性（r = -0.035，P＞0.05；r = -0.011，P＞0.05；r = -0.053，P＞0.05；r = -0.084，P＞0.05）和女性（r = 0.061，P＞0.05；r = 0.018，P＞0.05；r = 0.057，P＞0.05；r = -0.021，P＞0.05）的低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、总胆固醇（TC）和甘油三酯（TRIG）的血清脂联素与血脂之间均无关联。不同体重指数类别之间的血脂谱无差异。在尼日利亚成年研究人群中，个体的脂联素与血脂之间没有关系。
