First Department of Medicine, University of Debrecen, Debrecen, Hungary.
Pediatr Res. 2010 Mar;67(3):309-13. doi: 10.1203/PDR.0b013e3181c9fb66.
Childhood obesity is a predisposing factor for adult cardiovascular diseases. Human serum paraoxonase (PON1) may protect against atherosclerosis by hydrolyzing lipid peroxides in oxidized LDL. Alterations and potential correlations of PON1 activities, leptin and adiponectin levels in childhood obesity were studied. We measured PON1 paraoxonase and arylesterase activities, anthropometric parameters, leptin and adiponectin levels in 59 white, obese (obese group-OB: BMI corrected for age: 95.1 +/- 3.5 percentile, age: 11.9 +/- 1.6 y) and 51 normal-weight children (control group-C: BMI corrected for age: 64.1 +/- 8.4 percentile, age: 12.0 +/- 3.9 y). Obese children had significantly lower PON1 paraoxonase (OB: 84.80 (64.33/144.74) U/L versus. C: 99.42 (83.33/152.05) U/L; p < 0.05) and arylesterase activities (OB: 94.40 (82.20/108.70) U/L versus. C: 115.20 (93.70/126.00) U/L; p < 0.01), higher leptin (OB: 37.05 (24.33/53.87) ng/mL versus. C: 4.62 (2.52/17.6) ng/mL; p < 0.0001) and lower adiponectin levels (OB: 7.56 (5.69/12.06) microg/mL versus. C: 11.51 (8.84/14.49) microg/mL; p < 0.001) compared with the normal-weight group. PON1 arylesterase activity showed inverse univariate correlation with leptin (r = -0.29; p < 0.05) and positive correlation with adiponectin levels (r = 0.39; p < 0.01). In multiple regression analysis adiponectin was strongly associated with PON1 arylesterase activity in obese children (beta = 0.45, p < 0.02). Our results emphasize the importance of the investigated metabolic alterations which may have further effects on cardiovascular morbidity and mortality in later adulthood. Altered levels of leptin, adiponectin and PON1 activities may be useful markers beside the general risk factors in childhood obesity.
儿童肥胖是成年人心血管疾病的一个诱发因素。人血清对氧磷酶（PON1）通过水解氧化型 LDL 中的脂质过氧化物可能对动脉粥样硬化起到保护作用。本研究旨在探讨儿童肥胖症患者 PON1 活性、瘦素和脂联素水平的变化及其潜在相关性。我们测量了 59 名白人肥胖儿童（肥胖组 OB：体重指数校正年龄为 95.1±3.5%，年龄为 11.9±1.6 岁）和 51 名正常体重儿童（对照组 C：体重指数校正年龄为 64.1±8.4%，年龄为 12.0±3.9 岁）的 PON1 对氧磷酶和芳基酯酶活性、人体测量参数、瘦素和脂联素水平。肥胖儿童的 PON1 对氧磷酶（OB：84.80（64.33/144.74）U/L 与 C：99.42（83.33/152.05）U/L；p＜0.05）和芳基酯酶（OB：94.40（82.20/108.70）U/L 与 C：115.20（93.70/126.00）U/L；p＜0.01）活性显著降低，而瘦素（OB：37.05（24.33/53.87）ng/mL 与 C：4.62（2.52/17.6）ng/mL；p＜0.0001）和脂联素（OB：7.56（5.69/12.06）μg/mL 与 C：11.51（8.84/14.49）μg/mL；p＜0.001）水平显著升高。PON1 芳基酯酶活性与瘦素呈负相关（r=-0.29；p＜0.05），与脂联素呈正相关（r=0.39；p＜0.01）。多元回归分析显示，脂联素与肥胖儿童 PON1 芳基酯酶活性密切相关（β=0.45，p＜0.02）。本研究强调了这些代谢改变的重要性，这些改变可能对成年后患心血管疾病的发病率和死亡率有进一步影响。瘦素、脂联素和 PON1 活性水平的改变可能是儿童肥胖症一般危险因素之外的有用标志物。
