Sindermann Cornelia, Saliger Jochen, Nielsen Jörn, Karbe Hans, Markett Sebastian, Stavrou Maria, Montag Christian
Department of Molecular Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Neurological Rehabilitation Centre Godeshöhe, Bonn, Germany.
Arch Clin Neuropsychol. 2018 Aug 1;33(5):552-561. doi: 10.1093/arclin/acx104.
It remains an unresolved research objective to clarify the overlap/association between fatigue (especially its cognitive facet) and depression in People with MS (PwMS). Therefore, in this study the patterns of personality and primary emotional traits (PETs) associated with each (motoric/cognitive fatigue and depression in PwMS) were investigated and compared in order to disentangle the three constructs in PwMS. Additionally, differences in personality and PETs between PwMS and healthy controls (HC) were examined.
Associations between motoric/cognitive fatigue, depression, personality and PETs were investigated in 52 PwMS. Personality and PETs were also assessed in a gender matched HC sample (N = 52) and results regarding these were compared between PwMS and HC.
Low extraversion was the only significant predictor of MS related motoric fatigue (β = -.341, p = .013). High neuroticism was a predictor of both MS related cognitive fatigue (β = .426, p = .002) and depression (β = .443, p < .001). Whereas neuroticism was the only significant predictor for MS related cognitive fatigue, the cluster of (high) neuroticism, (high) SADNESS (β = .273, p = .023), and (low) extraversion (β = -.237, p = .025) predicted MS related depression. PwMS showed significantly higher scores in neuroticism and FEAR compared to HC.
MS related motoric/cognitive fatigue and depression in PwMS share variance. But the substantial amount of non-shared variance (motoric fatigue, depression: 72%; cognitive fatigue, depression: 66%) together with additional predictors for depression (SADNESS being a predictor of depression only), indicate that MS related motoric/cognitive fatigue and depression are distinguishable. Consequently, we recommend assessing especially SADNESS scores to distinguish between MS related fatigue and depression.
阐明多发性硬化症患者（PwMS）疲劳（尤其是其认知方面）与抑郁之间的重叠/关联仍是一个未解决的研究目标。因此，在本研究中，对与PwMS的每种情况（运动性/认知性疲劳和抑郁）相关的人格模式和主要情绪特质（PETs）进行了调查和比较，以便理清PwMS中的这三种结构。此外，还研究了PwMS与健康对照者（HC）在人格和PETs方面的差异。
对52名PwMS患者的运动性/认知性疲劳、抑郁、人格和PETs之间的关联进行了研究。还对一个性别匹配的HC样本（N = 52）进行了人格和PETs评估，并比较了PwMS与HC在这些方面的结果。
低外向性是与MS相关的运动性疲劳的唯一显著预测因素（β = -.341，p = .01）。高神经质是与MS相关的认知性疲劳（β = .426，p = .002）和抑郁（β = .443，p < .001）的预测因素。虽然神经质是与MS相关的认知性疲劳的唯一显著预测因素，但（高）神经质、（高）悲伤感（β = .273，p = .023）和（低）外向性（β = -.237，p = .025）的组合可预测与MS相关的抑郁。与HC相比，PwMS在神经质和恐惧方面的得分显著更高。
PwMS中与MS相关的运动性/认知性疲劳和抑郁存在共同变异。但大量的非共同变异（运动性疲劳、抑郁：72%；认知性疲劳、抑郁：66%）以及抑郁的其他预测因素（悲伤感仅是抑郁的预测因素）表明，与MS相关的运动性/认知性疲劳和抑郁是可区分的。因此，我们建议特别评估悲伤感得分，以区分与MS相关的疲劳和抑郁。
