Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
Laboratorio de Inmunología, Universidad de la República Regional Norte-Salto, Rivera 1350, CP 50000 Salto, Uruguay.
Nucleic Acids Res. 2018 Jan 4;46(D1):D645-D648. doi: 10.1093/nar/gkx1066.
Multitasking, or moonlighting, is the capability of some proteins to execute two or more biological functions. MultitaskProtDB-II is a database of multifunctional proteins that has been updated. In the previous version, the information contained was: NCBI and UniProt accession numbers, canonical and additional biological functions, organism, monomeric/oligomeric states, PDB codes and bibliographic references. In the present update, the number of entries has been increased from 288 to 694 moonlighting proteins. MultitaskProtDB-II is continually being curated and updated. The new database also contains the following information: GO descriptors for the canonical and moonlighting functions, three-dimensional structure (for those proteins lacking PDB structure, a model was made using Itasser and Phyre), the involvement of the proteins in human diseases (78% of human moonlighting proteins) and whether the protein is a target of a current drug (48% of human moonlighting proteins). These numbers highlight the importance of these proteins for the analysis and explanation of human diseases and target-directed drug design. Moreover, 25% of the proteins of the database are involved in virulence of pathogenic microorganisms, largely in the mechanism of adhesion to the host. This highlights their importance for the mechanism of microorganism infection and vaccine design. MultitaskProtDB-II is available at http://wallace.uab.es/multitaskII.
多任务处理，也称为兼职，是指一些蛋白质执行两个或更多生物功能的能力。MultitaskProtDB-II 是一个多功能蛋白质数据库，已经进行了更新。在前一版本中，包含的信息有：NCBI 和 UniProt 访问号、规范和其他生物功能、生物、单体/寡聚状态、PDB 代码和参考文献。在本次更新中，兼职蛋白的条目数从 288 个增加到了 694 个。MultitaskProtDB-II 正在不断被整理和更新。新数据库还包含以下信息：规范和兼职功能的 GO 描述符、三维结构（对于那些缺乏 PDB 结构的蛋白质，使用 Itasser 和 Phyre 构建了模型）、蛋白质在人类疾病中的参与（78%的人类兼职蛋白）以及该蛋白是否是当前药物的靶点（48%的人类兼职蛋白）。这些数字突出了这些蛋白质对于分析和解释人类疾病和靶向药物设计的重要性。此外，数据库中 25%的蛋白质参与致病微生物的毒力，主要是在与宿主粘附的机制中。这突出了它们在微生物感染和疫苗设计机制中的重要性。MultitaskProtDB-II 可在 http://wallace.uab.es/multitaskII 上获取。
