Breast Clinic, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Avenue Hippocrate, 10, 1200, Brussels, Belgium.
Breast Clinic, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Avenue Hippocrate, 10, 1200, Brussels, Belgium.
Breast. 2018 Feb;37:114-118. doi: 10.1016/j.breast.2017.10.017. Epub 2017 Nov 11.
In oncology, hypnosis has been used for pain relief in metastatic patients but rarely for induction of anesthesia.
Between January 2010 and October 2015, 300 patients from our Breast Clinic (Cliniques universitaires Saint-Luc, Université catholique de Louvain) were included in an observational, non-randomized study approved by our local ethics committee (ClinicalTrials.gov - NCT03003611). The hypothesis of our study was that hypnosis intervention could decrease side effects of breast surgery. 150 consecutive patients underwent breast surgery while on general anesthesia (group I), and 150 consecutive patients underwent the same surgical procedures while on hypnosis sedation (group II). After surgery, in each group, 32 patients received chemotherapy, radiotherapy was administered to 123 patients, and 115 patients received endocrine therapy.
Duration of hospitalization was statistically significantly reduced in group II versus group I: 3 versus 4.1 days (p = 0.0000057) for all surgical procedures. The number of post-mastectomy lymph punctures was reduced in group II (1-3, median value n = 1.5) versus group I (2-5, median value n = 3.1) (p = 0.01), as was the quantity of lymph removed (103 ml versus 462.7 ml) (p = 0.0297) in the group of mastectomies. Anxiety scale was also statistically reduced in the postoperative period among the group of patients undergoing surgery while on hypnosis sedation (p = 0.0000000000000002). The incidence of asthenia during chemotherapy was statistically decreased (p = 0.01) in group II. In this group, there was a statistically non-significant trend towards a decrease in the incidence of nausea/vomiting (p = 0.1), and the frequency of radiodermitis (p = 0.002) and post-radiotherapy asthenia (p = 0.000000881) was also reduced. Finally, the incidence of hot flashes (p = 0.0000000000021), joint and muscle pain (p = 0.0000000000021) and asthenia while on endocrine therapy (p = 0.000000022) were statistically significantly decreased in group II.
Hypnosis sedation exerts beneficial effects on nearly all modalities of breast cancer treatment.
Benefits of hypnosis sedation on breast cancer treatment are very encouraging and further promote the concept of integrative oncology.
在肿瘤学中，催眠已被用于缓解转移性患者的疼痛，但很少用于诱导麻醉。
2010 年 1 月至 2015 年 10 月，我们的乳腺诊所（圣吕克大学附属医院，天主教鲁汶大学）的 300 名患者被纳入一项经我们当地伦理委员会批准的观察性、非随机研究（ClinicalTrials.gov-NCT03003611）。我们的研究假设是，催眠干预可以减少乳房手术的副作用。150 名连续患者在全身麻醉下接受乳房手术（I 组），150 名连续患者在催眠镇静下接受相同的手术（II 组）。手术后，每组中有 32 名患者接受化疗，123 名患者接受放疗，115 名患者接受内分泌治疗。
与 I 组相比，II 组的住院时间明显缩短：所有手术为 3 天与 4.1 天（p=0.0000057）。与 I 组（2-5，中位数 n=3.1）相比，II 组（1-3，中位数 n=1.5）的乳房切除术后淋巴结穿刺次数减少（p=0.01），淋巴结切除量也减少（103ml 与 462.7ml）（p=0.0297）。接受乳房切除术的患者在术后期间焦虑量表也明显降低（p=0.0000000000000002）。接受化疗的乏力发生率也明显降低（p=0.01）。在该组中，恶心/呕吐的发生率呈统计学非显著下降趋势（p=0.1），放射性皮炎（p=0.002）和放疗后乏力（p=0.000000881）的频率也降低。最后，接受内分泌治疗的热潮红（p=0.0000000000021）、关节和肌肉疼痛（p=0.0000000000021）和乏力的发生率在 II 组中统计学显著降低。
催眠镇静对乳腺癌治疗的几乎所有方式都有有益的影响。
催眠镇静对乳腺癌治疗的益处非常令人鼓舞，并进一步促进了综合肿瘤学的概念。
Zotero 插件