Pharmacy College, Chongqing Medical University, Chongqing 400016, China.
Molecules. 2017 Nov 11;22(11):1952. doi: 10.3390/molecules22111952.
A selective and practical bromine-metal exchange on bromoheterocyclics bearing substituents with an acidic proton under non-cryogenic conditions was developed by a simple modification of an existing protocol. Our protocol of using a combination of i-PrMgCl and n-BuLi has not only solved the problem of intermolecular quenching that often occurred when using alkyl lithium alone as the reagent for halogen-lithium exchange, but also offered a highly selective method for performing bromo-metal exchange on dibrominated arene compounds through chelation effect.
在非低温条件下，通过对带有酸性质子取代基的溴杂环进行选择性和实用的溴-金属交换反应，对现有方案进行了简单的改进。我们使用 i-PrMgCl 和 n-BuLi 的组合的方案不仅解决了单独使用烷基锂作为卤-锂交换试剂时经常发生的分子间猝灭问题，而且还通过螯合效应提供了一种在二溴芳烃化合物上进行溴-金属交换的高度选择性方法。
