Eoh Kyung Jin, Kim Hee Jung, Lee Jung-Yun, Nam Eun Ji, Kim Sunghoon, Kim Sang Wun, Kim Young Tae
Institute of Women's Medical Life Science, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Oncotarget. 2017 Sep 16;8(48):84396-84402. doi: 10.18632/oncotarget.21041. eCollection 2017 Oct 13.
family members encode transcription factors crucial for embryogenesis and may be associated with carcinogenesis. Here, we evaluated the expression of 39 genes in cervical cancer by using clinicopathological information and gene expression data of 308 patients from The Cancer Genome Atlas (TCGA) database. Correlations between mRNA expression of HOX family members and clinicopathological variables were explored. Seventy-three (23.7%) patients died during the follow-up period (median, 22.0 months). Overall mortality was significantly associated with advanced FIGO stage, lymph node metastasis, lymphovascular invasion, and increased , , , and mRNA expression. Kaplan-Meier survival analysis revealed that overall survival was significantly shorter in patients with high rather than low expression (, P = 0.012; , P = 0.008; and , P = 0.006). Upregulated , , and expression are significantly correlated with unfavorable overall survival and increased mortality in cervical cancer patients. Therefore, expression is a potential cervical cancer prognostic indicator.
家族成员编码对胚胎发育至关重要的转录因子，且可能与癌症发生相关。在此，我们利用来自癌症基因组图谱（TCGA）数据库的308例患者的临床病理信息和基因表达数据，评估了39个基因在宫颈癌中的表达情况。探讨了HOX家族成员的mRNA表达与临床病理变量之间的相关性。73例（23.7%）患者在随访期间死亡（中位随访时间为22.0个月）。总体死亡率与国际妇产科联盟（FIGO）晚期分期、淋巴结转移、脉管浸润以及HOXA1、HOXA10、HOXB13和HOXC13 mRNA表达增加显著相关。Kaplan-Meier生存分析显示，HOXA1、HOXA10或HOXB13高表达患者的总生存期明显短于低表达患者（HOXA1：HR = 2.504，P = 0.012；HOXA10：HR = 3.012，P = 0.008；HOXB13：HR = 3.245，P = 0.006）。HOXA1、HOXA10和HOXB13表达上调与宫颈癌患者不良的总生存期和死亡率增加显著相关。因此，HOXB13表达是一种潜在的宫颈癌预后指标。
