Rezaee Aryan, Ahmadpour Sara, Jafari Ameneh, Aghili Sarehnaz, Zadeh Seyed Saeed Tamehri, Rajabi Ali, Raisi Arash, Hamblin Michael R, Mahjoubin-Tehran Maryam, Derakhshan Marzieh
Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Biotechnology Department, Faculty of Chemistry, University of Kashan, Kashan, Iran.
Front Oncol. 2023 Oct 3;13:1215194. doi: 10.3389/fonc.2023.1215194. eCollection 2023.
Gynecologic cancer is a significant cause of death in women worldwide, with cervical cancer, ovarian cancer, and endometrial cancer being among the most well-known types. The initiation and progression of gynecologic cancers involve a variety of biological functions, including angiogenesis and metastasis-given that death mostly occurs from metastatic tumors that have invaded the surrounding tissues. Therefore, understanding the molecular pathways underlying gynecologic cancer metastasis is critical for enhancing patient survival and outcomes. Recent research has revealed the contribution of numerous non-coding RNAs (ncRNAs) to metastasis and invasion of gynecologic cancer by affecting specific cellular pathways. This review focuses on three types of gynecologic cancer (ovarian, endometrial, and cervical) and three kinds of ncRNAs (long non-coding RNAs, microRNAs, and circular RNAs). We summarize the detailed role of non-coding RNAs in the different pathways and molecular interactions involved in the invasion and metastasis of these cancers.
妇科癌症是全球女性死亡的一个重要原因，宫颈癌、卵巢癌和子宫内膜癌是其中最广为人知的类型。妇科癌症的发生和发展涉及多种生物学功能，包括血管生成和转移——因为死亡大多是由侵入周围组织的转移性肿瘤导致的。因此，了解妇科癌症转移的分子途径对于提高患者生存率和改善治疗结果至关重要。最近的研究表明，许多非编码RNA（ncRNA）通过影响特定细胞途径，对妇科癌症的转移和侵袭有促进作用。本综述聚焦于三种妇科癌症（卵巢癌、子宫内膜癌和宫颈癌）以及三种ncRNA（长链非编码RNA、微小RNA和环状RNA）。我们总结了非编码RNA在这些癌症侵袭和转移所涉及的不同途径及分子相互作用中的具体作用。
