Kostev Karel, Meister Uwe, Kalder Matthias, Jacob Louis
Epidemiology, QuintilesIMS, Frankfurt, Germany.
GP Praxis Meister, Nidderau, Germany.
Oncotarget. 2017 Sep 14;8(48):84540-84545. doi: 10.18632/oncotarget.20886. eCollection 2017 Oct 13.
The goal of the present study was to analyze the prevalence and risk factors of suspected cancer diagnoses made by general practitioners (GP) in a population with subsequently confirmed cancer diagnoses in Germany. This study included patients aged 18 years or older who received an initial documentation of a confirmed cancer diagnosis from 1,262 German GP between January and December 2016 (index date). The main outcome measure of the study was the rate of suspected cancer diagnoses made by GP within one year prior to the index date. A multivariate logistic regression model was used to estimate the relationship between defined demographic and clinical variables and suspected cancer diagnoses. This study included 31,628 individuals. Within the year prior to the confirmed cancer diagnosis, 5% of the population received suspected cancer diagnoses. Patients in the age groups 41-50, 51-60, and 61-70 years were more likely to receive a suspected cancer diagnosis from a GP than those in the age group > 80 years (OR ranging from 1.30 to 1.38). Lung cancer, skin cancer, prostate cancer, and leukemia were associated with an increase in such odds when compared to cancers of the digestive organs (OR ranging from 1.56 to 2.26), whereas female genital organ cancers were associated with decreased odds (OR = 0.63). Overall, approximately 5% of patients received suspected diagnoses of cancer prior to their confirmed diagnoses. Suspected cancer diagnoses were associated with age and several types of cancer.
本研究的目的是分析德国全科医生(GP)对随后确诊为癌症的人群进行疑似癌症诊断的患病率和风险因素。本研究纳入了年龄在18岁及以上的患者,这些患者在2016年1月至12月期间从1262名德国全科医生处获得了确诊癌症的初始记录(索引日期)。该研究的主要结局指标是全科医生在索引日期前一年内做出的疑似癌症诊断率。使用多因素逻辑回归模型来估计定义的人口统计学和临床变量与疑似癌症诊断之间的关系。本研究共纳入31628名个体。在确诊癌症之前的一年中,5%的人群接受了疑似癌症诊断。41 - 50岁、51 - 60岁和61 - 70岁年龄组的患者比80岁以上年龄组的患者更有可能从全科医生处获得疑似癌症诊断(比值比范围为1.30至1.38)。与消化器官癌症相比,肺癌、皮肤癌、前列腺癌和白血病的此类比值增加(比值比范围为1.56至2.26),而女性生殖器官癌症的比值降低(比值比 = 0.63)。总体而言,约5%的患者在确诊癌症之前接受了疑似癌症诊断。疑似癌症诊断与年龄和几种癌症类型有关。