Tresch D D, Thakur R K, Hoffmann R G, Olson D, Brooks H L
Division of Cardiology, Medical College of Wisconsin, Milwaukee 53226.
Am J Med. 1989 Feb;86(2):145-50. doi: 10.1016/0002-9343(89)90259-3.
Elderly and younger patients who were successfully resuscitated and hospitalized following out-of-hospital cardiac arrest were studied to determine if there was a significant difference in hospital course and long-term survival between the two groups.
The study consisted of 214 consecutive patients, divided into two age groups: elderly (more than 70 years, n = 112) and younger (less than 70 years, n = 102). Hospital charts and paramedic run data were retrospectively reviewed for each patient and findings were compared between the two age groups.
Prior to cardiac arrest, 47 of 112 (42 percent) elderly patients had a history of heart failure, compared with 19 of 102 (18 percent) younger patients, and were more commonly taking digitalis (51 percent versus 29 percent) and diuretics (47 percent versus 26 percent). Younger patients, however, more often had an acute myocardial infarction at the time of the cardiac arrest (33 percent versus 16 percent). At the time of cardiac arrest, 83 percent of younger patients demonstrated ventricular fibrillation, compared with 71 percent of the elderly. In contrast, electromechanical dissociation was five times more common in the elderly patients. Although hospital deaths were more common in the elderly (71 percent versus 53 percent), the length of hospitalization and stay in intensive care units were not significantly different between the age groups. The number of neurologic deaths was similar in both age groups, as were residual neurologic impairments. Only five elderly patients and six younger patients required placement in extended-care facilities. Calculated long-term survival curves demonstrated similar survival in both age groups, with approximately 65 percent of hospital survivors alive at 24 months after hospital discharge.
Resuscitation of elderly patients in whom out-of-hospital cardiac arrest occurs is reasonable and appropriate, according to the findings of this study. Even though elderly patients are more likely than younger patients to die during hospitalization, the hospital stay of the elderly is not longer, the elderly do not have more residual neurologic impairments, and survival after hospital discharge is similar to that in younger patients.
对院外心脏骤停后成功复苏并住院的老年患者和年轻患者进行研究,以确定两组患者在住院过程和长期生存方面是否存在显著差异。
该研究纳入了214例连续患者,分为两个年龄组:老年组(70岁以上,n = 112)和年轻组(70岁以下,n = 102)。对每位患者的医院病历和急救人员出诊数据进行回顾性分析,并比较两个年龄组的结果。
心脏骤停前,112例老年患者中有47例(42%)有心力衰竭病史,而102例年轻患者中有19例(约18%)有心力衰竭病史,且老年患者更常服用洋地黄(51% 对 29%)和利尿剂(47% 对 26%)。然而,年轻患者在心脏骤停时更常发生急性心肌梗死(33% 对 16%)。心脏骤停时,83% 的年轻患者表现为心室颤动,而老年患者为71%。相比之下,电机械分离在老年患者中更为常见,是年轻患者的5倍。尽管老年患者的院内死亡更为常见(71% 对 53%),但两个年龄组的住院时间和重症监护病房停留时间并无显著差异。两个年龄组的神经源性死亡数量相似,残留神经功能障碍情况也相似。只有5例老年患者和6例年轻患者需要安置在长期护理机构。计算得出的长期生存曲线显示,两个年龄组的生存率相似,出院后24个月时约65% 的住院幸存者仍存活。
根据本研究结果,对发生院外心脏骤停的老年患者进行复苏是合理且恰当的。尽管老年患者比年轻患者在住院期间更易死亡,但老年患者的住院时间并不更长,残留神经功能障碍也并不更多,出院后的生存率与年轻患者相似。