Nathanson Neil M
Department of Pharmacology, School of Medicine, University of Washington, Box 357750, Seattle, WA 98195-7750, USA.
Pharmacol Ther. 2008 Jul;119(1):33-43. doi: 10.1016/j.pharmthera.2008.04.006. Epub 2008 May 16.
Muscarinic acetylcholine receptors are members of the G-protein coupled receptor superfamily that are expressed in and regulate the function of neurons, cardiac and smooth muscle, glands, and many other cell types and tissues. The correct trafficking of membrane proteins to the cell surface and their subsequent localization at appropriate sites in polarized cells are required for normal cellular signaling and physiological responses. This review will summarize work on the synthesis and trafficking of muscarinic receptors to the plasma membrane and their localization at the cell surface.
毒蕈碱型乙酰胆碱受体是G蛋白偶联受体超家族的成员,在神经元、心脏和平滑肌、腺体以及许多其他细胞类型和组织中表达并调节其功能。膜蛋白正确转运到细胞表面并随后定位于极化细胞的适当部位,对于正常的细胞信号传导和生理反应是必需的。本综述将总结关于毒蕈碱受体合成、转运到质膜及其在细胞表面定位的研究工作。