UMR Physiologie de la Nutrition et du Comportement Alimentaire, AgroParisTech, Institut National de la Recherche Agronomique, Université Paris Saclay , Paris , France.
Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E139-E151. doi: 10.1152/ajpendo.00318.2017. Epub 2017 Nov 14.
Low protein (LP)-containing diets can induce overeating in rodents and possibly in humans in an effort to meet protein requirement, but the effects on energy expenditure (EE) are unclear. The present study evaluated the changes induced by reducing dietary protein from 20% to 6%-using either soy protein or casein-on energy intake, body composition, and EE in mice housed at 22°C or at 30°C (thermal neutrality). LP feeding increased energy intake and adiposity, more in soy-fed than in casein-fed mice, but also increased EE, thus limiting fat accumulation. The increase in EE was due mainly to an increase in spontaneous motor activity related to EE and not to thermoregulation. However, the high cost of thermoregulation at 22°C and the subsequent heat exchanges between nonshivering thermogenesis, motor activity, and feeding induced large differences in adaptation between mice housed at 22°C and at 30°C.
低蛋白（LP）饮食可诱导啮齿动物，可能也可诱导人类过度进食，以满足蛋白质需求，但对能量消耗的影响尚不清楚。本研究评估了通过将饮食中的蛋白质从 20%降低到 6%（使用大豆蛋白或酪蛋白）对 22°C 或 30°C（热中性）环境中饲养的小鼠的能量摄入、身体成分和能量消耗的影响。LP 喂养增加了能量摄入和肥胖，大豆蛋白喂养的小鼠比酪蛋白喂养的小鼠更明显，但也增加了能量消耗，从而限制了脂肪堆积。能量消耗的增加主要归因于与能量消耗相关的自发运动活动的增加，而不是体温调节。然而，22°C 时体温调节的高成本以及非寒战产热、运动活动和进食之间的随后热量交换，导致了在 22°C 和 30°C 环境中饲养的小鼠之间在适应方面的巨大差异。
