Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN
J Cell Biol. 2017 Dec 4;216(12):3891-3893. doi: 10.1083/jcb.201710028. Epub 2017 Nov 14.
Establishment of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis of human pluripotent stem cells (hPSCs). In this issue, Taniguchi et al. (2017. https://doi.org/10.1083.jcb201704085) describe a structure called the apicosome, generated in single hPSCs, that allows them to self-organize and form the lumenal epiblast-like stage.
顶端-基底极性的建立对于人多能干细胞(hPSCs)的腔上皮样形态发生至关重要。在本期中,Taniguchi 等人(2017. https://doi.org/10.1083/jcb201704085)描述了一种称为顶体小泡的结构,它在单个 hPSC 中产生,使它们能够自我组织并形成腔上皮样阶段。