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顶端极化和腔形成:顶体小泡带来新的曙光。

Apical polarization and lumenogenesis: The apicosome sheds new light.

机构信息

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN.

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN

出版信息

J Cell Biol. 2017 Dec 4;216(12):3891-3893. doi: 10.1083/jcb.201710028. Epub 2017 Nov 14.

DOI:10.1083/jcb.201710028
PMID:29138252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5716292/
Abstract

Establishment of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis of human pluripotent stem cells (hPSCs). In this issue, Taniguchi et al. (2017. https://doi.org/10.1083.jcb201704085) describe a structure called the apicosome, generated in single hPSCs, that allows them to self-organize and form the lumenal epiblast-like stage.

摘要

顶端-基底极性的建立对于人多能干细胞(hPSCs)的腔上皮样形态发生至关重要。在本期中,Taniguchi 等人(2017. https://doi.org/10.1083/jcb201704085)描述了一种称为顶体小泡的结构,它在单个 hPSC 中产生,使它们能够自我组织并形成腔上皮样阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/5716292/a8f597b5f037/JCB_201710028_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/5716292/a8f597b5f037/JCB_201710028_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0646/5716292/a8f597b5f037/JCB_201710028_Fig1.jpg

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本文引用的文献

1
An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.顶体启动人类多能干细胞的自组织形态发生。
J Cell Biol. 2017 Dec 4;216(12):3981-3990. doi: 10.1083/jcb.201704085. Epub 2017 Oct 11.
2
Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis.胚胎样细胞团、类器官和类原肠胚:理解胚胎发育的新方法。
Development. 2017 Mar 15;144(6):976-985. doi: 10.1242/dev.143529.
3
Self-organization of the human embryo in the absence of maternal tissues.在没有母体组织的情况下人类胚胎的自我组织。
Nat Cell Biol. 2016 Jun;18(6):700-708. doi: 10.1038/ncb3347. Epub 2016 May 4.
4
Self-organization of the in vitro attached human embryo.体外附着人类胚胎的自组织。
Nature. 2016 May 12;533(7602):251-4. doi: 10.1038/nature17948. Epub 2016 May 4.
5
Human embryology: Implantation barrier overcome.人类胚胎学:克服着床屏障。
Nature. 2016 May 12;533(7602):182-3. doi: 10.1038/nature17894. Epub 2016 May 4.
6
Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells.腔形成是分离的人类多能干细胞的固有特性。
Stem Cell Reports. 2015 Dec 8;5(6):954-962. doi: 10.1016/j.stemcr.2015.10.015. Epub 2015 Nov 25.
7
Differences in the Early Development of Human and Mouse Embryonic Stem Cells.人类和小鼠胚胎干细胞早期发育的差异
PLoS One. 2015 Oct 16;10(10):e0140803. doi: 10.1371/journal.pone.0140803. eCollection 2015.
8
In vitro culture of mouse blastocysts beyond the implantation stages.体外培养小鼠囊胚至着床后阶段。
Nat Protoc. 2014 Dec;9(12):2732-9. doi: 10.1038/nprot.2014.186. Epub 2014 Oct 30.
9
In-vitro model systems for the study of human embryo-endometrium interactions.用于研究人胚胎-子宫内膜相互作用的体外模型系统。
Reprod Biomed Online. 2013 Nov;27(5):461-76. doi: 10.1016/j.rbmo.2013.08.002. Epub 2013 Aug 28.
10
Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance.内吞运输和胞质分裂:从细胞骨架的调节到中体的遗传。
Trends Cell Biol. 2013 Jul;23(7):319-27. doi: 10.1016/j.tcb.2013.02.003. Epub 2013 Mar 20.