Sukhani R, Winnie A P
Department of Anesthesiology, University of Illinois College of Medicine, Chicago.
Anesth Analg. 1989 Feb;68(2):90-3. doi: 10.1213/00000539-198902000-00003.
To compare serum levels of lidocaine resulting from 1.1% lidocaine carbonate and 1.0% lidocaine hydrochloride, the two salts were administered to ten healthy adult patients undergoing upper extremity surgery under interscalene brachial plexus block. Epinephrine (1:200,000) was added to both the solutions just prior to injection, and, following performance of the blocks, venous blood samples were drawn at 3, 5, 10, 15, 20, 30, 60 and 120 minutes. The concentration of lidocaine tended to rise more rapidly and to achieve higher levels in the first 10 minutes following injection of the carbonated lidocaine. However, no significant differences were found in the parameters of Cmax, Tmax or AUC for the two salts, and the serum levels in both groups at all times were well below the levels known to produce systemic toxicity. Therefore, while previous studies appear to indicate that the carbonate salt enhances diffusion, penetration, and uptake of neural tissues as compared with the hydrochloride salt, the present study indicates that vascular uptake is not similarly affected.
为比较1.1%碳酸利多卡因和1.0%盐酸利多卡因产生的血清利多卡因水平，将这两种盐分别给予10例接受肌间沟臂丛阻滞下行上肢手术的健康成年患者。在注射前，两种溶液均加入肾上腺素（1:200,000），在完成阻滞操作后，于3、5、10、15、20、30、60和120分钟采集静脉血样本。注射碳酸利多卡因后的前10分钟内，利多卡因浓度升高更快且达到更高水平。然而，两种盐在Cmax、Tmax或AUC参数上未发现显著差异，两组在所有时间的血清水平均远低于已知会产生全身毒性的水平。因此，虽然先前的研究似乎表明与盐酸盐相比，碳酸盐可增强神经组织的扩散、渗透和摄取，但本研究表明血管摄取并未受到类似影响。
