Sukhani R, Winnie A P
Department of Anesthesiology, University of Illinois Medical Center at Chicago.
Anesth Analg. 1987 Dec;66(12):1245-50.
A double-blind comparison of 1.1% lidocaine carbonate and 1.0% lidocaine hydrochloride was carried out in 30 healthy adult patients undergoing upper-extremity surgery under interscalene brachial plexus block. Epinephrine (1:200,000) was added to both solutions just before injection. As compared to lidocaine hydrochloride, lidocaine carbonate produced, in addition to a 38% reduction in onset time, a remarkable increase in the extent of anesthesia: lidocaine carbonate produced surgical anesthesia of the entire upper extremity including the hand in 87% of the patients, whereas lidocaine hydrochloride produced similar anesthesia in only 53% of the patients. Thus, supplemental blocks were required in 66% of the patients who received lidocaine hydrochloride, whereas they were required in only 25% of those who received lidocaine carbonate.
在30例接受肌间沟臂丛阻滞下行上肢手术的健康成年患者中，对1.1%碳酸利多卡因和1.0%盐酸利多卡因进行了双盲比较。在注射前，两种溶液中均加入肾上腺素（1:200,000）。与盐酸利多卡因相比，碳酸利多卡因除起效时间缩短38%外，麻醉范围显著增加：87%接受碳酸利多卡因的患者上肢包括手部产生了手术麻醉，而接受盐酸利多卡因的患者中只有53%产生了类似麻醉。因此，接受盐酸利多卡因的患者中有66%需要追加阻滞，而接受碳酸利多卡因的患者中只有25%需要追加阻滞。
