McEllistrem R F, Schell J, O'Malley K, O'Toole D, Cunningham A J
Department of Anaesthesia, Royal College of Surgeons, Dublin, Ireland.
Can J Anaesth. 1989 Jan;36(1):59-63. doi: 10.1007/BF03010889.
Plasma lidocaine concentrations, latency of onset, and duration of anaesthesia, were determined after interscalene brachial plexus block in 16 patients presenting for elective upper limb surgery. Eight patients had normal renal function and eight had chronic renal failure, as determined by creatinine clearance. Significantly higher plasma lidocaine levels were recorded ten minutes after infiltration in patients with chronic renal failure (p less than 0.05). Cmax plasma levels for normal patients (5.6 +/- 1.1 micrograms.ml-1) and for patients with chronic renal failure (6.6 +/- 1.6 micrograms.ml-1) were not significantly different. The latency of onset and duration of anaesthesia were similar in both groups. One per cent lidocaine solution may be administered to patients with normal and impaired renal function to provide effective brachial plexus blockade for short surgical procedures.
对16例择期进行上肢手术的患者行肌间沟臂丛神经阻滞，测定血浆利多卡因浓度、起效潜伏期和麻醉持续时间。根据肌酐清除率判断，8例患者肾功能正常，8例患者患有慢性肾衰竭。慢性肾衰竭患者浸润后10分钟记录到的血浆利多卡因水平显著更高（p小于0.05）。正常患者（5.6±1.1微克·毫升⁻¹）和慢性肾衰竭患者（6.6±1.6微克·毫升⁻¹）的血浆Cmax水平无显著差异。两组的起效潜伏期和麻醉持续时间相似。对于肾功能正常和受损的患者，均可给予1%利多卡因溶液，以在短时间手术中提供有效的臂丛神经阻滞。
