Gernone Floriana, Ricciardi Mario
"Pingry" Veterinary Hospital, via Medaglie d'Oro 5, Bari, Italy.
Open Vet J. 2017;7(4):313-318. doi: 10.4314/ovj.v7i4.4. Epub 2017 Nov 6.
Thiamine is a water-soluble vitamin, which participates in several vital metabolic pathways involved in energy metabolism and neurotransmitter synthesis of mammals. In companion animals thiamine deficiency is classically associated with signs of diffuse encephalopathy and lesions on brainstem nuclei and mesencephalic colliculi evident on magnetic resonance imaging. This paper describes a novel clinical presentation in a thiamine-deficient dog showing multifocal, central and peripheral nervous and cardiovascular system alterations. Brain MRI showed bilateral caudate nuclei damage, with necrotic-malacic evolution, similar to the atypical MRI pattern found in Wernicke's encephalopathy in humans. Detection of bilateral symmetrical lesions of the caudate nuclei in dogs should prompt consideration of a thiamine deficiency among the differential diagnoses.
硫胺素是一种水溶性维生素，它参与哺乳动物能量代谢和神经递质合成所涉及的多种重要代谢途径。在伴侣动物中，硫胺素缺乏通常与弥漫性脑病的症状以及磁共振成像显示的脑干核和中脑丘的病变有关。本文描述了一只硫胺素缺乏犬的一种新的临床表现，该犬出现多灶性、中枢和外周神经及心血管系统改变。脑部磁共振成像显示双侧尾状核损伤，并伴有坏死软化演变，类似于人类韦尼克脑病中发现的非典型磁共振成像模式。犬双侧尾状核出现对称性病变时，在鉴别诊断中应考虑硫胺素缺乏。
