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钝性脾损伤和肝损伤非手术治疗后的长期随访:一项基于问卷的调查

Long-Term Follow-Up After Non-operative Management of Blunt Splenic and Liver Injuries: A Questionnaire-Based Survey.

作者信息

Moreno Peter, Von Allmen Matthias, Haltmeier Tobias, Candinas Daniel, Schnüriger Beat

机构信息

Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.

出版信息

World J Surg. 2018 May;42(5):1358-1363. doi: 10.1007/s00268-017-4336-5.

Abstract

BACKGROUND

Non-operative management (NOM) of blunt splenic or liver injuries (solid organ injury, SOI) has become the standard of care in hemodynamically stable patients. However, the incidence of long-term symptoms in these patients is currently not known. The aim of this study was to assess long-term symptoms in patients undergoing successful NOM (sNOM) for SOI.

METHODS

Long-term posttraumatic outcomes including chronic abdominal pain, irregular bowel movements, and recurrent infections were assessed using a specifically designed questionnaire and analyzed by univariable analysis.

RESULTS

Eighty out of 138 (58%) patients with SOI undergoing sNOM) responded to the questionnaire. Median (IQR) follow-up time was 48.8 (28) months. Twenty-seven (34%) patients complained of at least one of the following symptoms: 17 (53%) chronic abdominal pain, 13 (41%) irregular bowel movements, and 8 (25%) recurrent infections. One female patient reported secondary infertility. No significant association between the above-mentioned symptoms and the Injury Severity Score, amount of hemoperitoneum, or high-grade SOI was found. Patients with chronic pain were significantly younger than asymptomatic patients (32.1 ± 14.5 vs. 48.3 ± 19.4 years, p = 0.002). Irregular bowel movements were significantly more frequent in patients with severe pelvic fractures (15.4 vs. 0.0%, p = 0.025). A trend toward a higher frequency of recurrent infections was found in patients with splenic injuries (15.9 vs. 2.8%, p = 0.067).

CONCLUSION

A third of patients with blunt SOI undergoing sNOM reported long-term abdominal symptoms. Younger age was associated with chronic abdominal symptoms. More studies are warranted to investigate long-term outcomes immunologic sequelae in patients after sNOM for SOI.

摘要

背景

钝性脾或肝损伤(实体器官损伤,SOI)的非手术治疗(NOM)已成为血流动力学稳定患者的标准治疗方法。然而,目前尚不清楚这些患者长期症状的发生率。本研究的目的是评估因SOI接受成功非手术治疗(sNOM)的患者的长期症状。

方法

使用专门设计的问卷评估长期创伤后结局,包括慢性腹痛、排便习惯改变和反复感染,并进行单变量分析。

结果

138例接受sNOM的SOI患者中有80例(58%)回复了问卷。中位(IQR)随访时间为48.8(28)个月。27例(34%)患者抱怨至少出现以下一种症状:17例(53%)慢性腹痛,13例(41%)排便习惯改变,8例(25%)反复感染。一名女性患者报告继发性不孕。未发现上述症状与损伤严重程度评分、腹腔积血量或高级别SOI之间存在显著关联。慢性疼痛患者明显比无症状患者年轻(32.1±14.5岁对48.3±19.4岁,p=0.002)。严重骨盆骨折患者排便习惯改变明显更频繁(15.4%对0.0%,p=0.025)。脾损伤患者反复感染频率有升高趋势(15.9%对2.8%,p=0.067)。

结论

接受sNOM的钝性SOI患者中有三分之一报告有长期腹部症状。年龄较小与慢性腹部症状有关。有必要进行更多研究以调查SOI患者接受sNOM后的长期结局和免疫后遗症。

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