Rabinovitch S, Greyson N D, Weiser W, Hoffstein V
Department of Nuclear Medicine, University of Toronto, St. Michael's Hospital, Ontario, Canada.
Am Rev Respir Dis. 1989 Feb;139(2):556-8. doi: 10.1164/ajrccm/139.2.556.
We present clinical and laboratory results (including nuclear imaging) obtained over a period of two years in two nonsmoking miners who were exposed to high concentrations of sulfur dioxide (SO2) after a mine explosion. Within 3 wk of the accident, both miners had evidence of severe airways obstruction, hypoxemia, markedly reduced exercise tolerance, ventilation-perfusion mismatch, and evidence of active inflammation as documented by positive gallium lung scan. Serial ventilation-perfusion scans over the first 12 months showed progressive improvement without returning to normal. After the initial recovery, there has been no significant change over the subsequent two years postinjury. Pulmonary function and exercise tests also displayed a similar pattern of initial improvement. We conclude that (1) acute exposure to high concentrations of SO2 results in severe airways obstruction, (2) pulmonary function abnormalities are partially reversible, and (3) most of the improvement occurs within 12 months after the initial injury.
我们展示了两名不吸烟矿工在矿井爆炸后暴露于高浓度二氧化硫（SO2）环境中两年期间获得的临床和实验室结果（包括核成像）。事故发生后3周内，两名矿工均出现严重气道阻塞、低氧血症、运动耐力显著下降、通气-灌注不匹配，以及镓肺扫描阳性所证明的活动性炎症迹象。在最初的12个月内进行的系列通气-灌注扫描显示病情逐渐改善，但未恢复正常。在最初恢复后，受伤后的随后两年中没有显著变化。肺功能和运动测试也呈现出类似的最初改善模式。我们得出结论：（1）急性暴露于高浓度SO2会导致严重气道阻塞；（2）肺功能异常部分可逆；（3）大部分改善发生在最初受伤后的12个月内。
