Charan N B, Myers C G, Lakshminarayan S, Spencer T M
Am Rev Respir Dis. 1979 Apr;119(4):555-60. doi: 10.1164/arrd.1979.119.4.555.
This report describes an industrial accident in which 5 previously healthy persons were acutely exposed to very high concentrations of sulfur dioxide. Of these 5 subjects, the 2 with the highest exposure died immediately; histologic examination of the lungs revealed extensive sloughing of the mucosa of large and small airways along with hemorrhagic alveolar edema. The 3 survivors were evaluated with pulmonary function tests performed at regular intervals. One subject subsequently developed symptomatic severe airway obstruction unresponsive to bronchodilators; another subject developed asymptomatic mild obstructive and restrictive disease, and the third subject continued to be asymptomatic with normal pulmonary function tests. This report severe to document the histologic features of fatal exposure to sulfur dioxide and stresses the need to follow parameters of pulmonary function in the nonfatal cases.
本报告描述了一起工业事故，5名此前健康的人员急性暴露于极高浓度的二氧化硫中。在这5名受试者中，暴露程度最高的2人立即死亡；肺部组织学检查显示，大小气道黏膜广泛脱落，伴有出血性肺泡水肿。对3名幸存者定期进行肺功能测试评估。一名受试者随后出现了对支气管扩张剂无反应的症状性严重气道阻塞；另一名受试者出现了无症状的轻度阻塞性和限制性疾病，第三名受试者肺功能测试结果正常，仍无症状。本报告旨在记录致命性二氧化硫暴露的组织学特征，并强调在非致命病例中跟踪肺功能参数的必要性。
