Härkönen H, Nordman H, Korhonen O, Winblad I
Am Rev Respir Dis. 1983 Nov;128(5):890-3. doi: 10.1164/arrd.1983.128.5.890.
The lung function of 7 men accidentally exposed to sulfur dioxide (SO2) in a pyrite dust explosion was followed for 4 yr. The greatest decrease in forced vital capacity, forced expiratory volume in one second, and maximal midexpiratory flow was observed 1 wk after the accident. After about 3 months no further decrement occurred. The pattern of spirometric findings was obstructive in 6 and restrictive in 1 of the patients. Four years after the accident a reversible obstruction of the bronchi was still observable in 3. Four patients reacted positively to the histamine challenge test. Two patients either did not respond to bronchodilator or did not react to histamine. The results suggest that bronchial hyperreactivity is a frequent sequela after exposure to high concentrations of SO2. The hyperreactivity may persist for several years.
对7名在黄铁矿粉尘爆炸中意外接触二氧化硫（SO₂）的男性的肺功能进行了4年的跟踪研究。事故发生1周后，观察到用力肺活量、一秒用力呼气量和最大呼气中期流速下降最为明显。约3个月后未再出现进一步下降。肺活量测定结果显示，6例患者为阻塞性，1例为限制性。事故发生4年后，仍有3例患者存在可逆性支气管阻塞。4例患者对组胺激发试验反应呈阳性。2例患者对支气管扩张剂无反应或对组胺无反应。结果表明，支气管高反应性是高浓度SO₂暴露后的常见后遗症。这种高反应性可能会持续数年。
