泽泻中的原萜烷型三萜类化合物。
Protostane-Type Triterpenoids from Alisma orientale.
作者信息
Li Hong-Mei, Chen Xue-Jiao, Luo Dan, Fan Min, Zhang Zhi-Jun, Peng Li-Yan, Wu Xing-De, Li Rong-Tao, Ji Xu, Zhao Qin-Shi
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
出版信息
Chem Biodivers. 2017 Dec;14(12). doi: 10.1002/cbdv.201700452.
Twenty-eight protostane triterpenoids, including a new degraded one (1), nine new ones (2 - 10), and two new natural ones (11 and 12), have been isolated from the dried rhizomes of Alisma orientale. Alisol R (1) was the first 20,21,22,23,24,25,26,27-octanorprotostane triterpenoid. The absolute configurations of 25-methoxyalisol F (2) and 16β-hydroperoxyalisol B 23-acetate (3) were determined by X-ray diffraction analysis. In addition, alismaketone-B 23-acetate (28) showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.
从泽泻干燥根茎中分离出了28种原萜烷三萜类化合物，包括一种新的降解产物（1）、9种新化合物（2 - 10）以及两种新的天然产物（11和12）。泽泻醇R（1）是首个20,21,22,23,24,25,26,27-八降原萜烷三萜类化合物。通过X射线衍射分析确定了25-甲氧基泽泻醇F（2）和16β-氢过氧泽泻醇B 23-乙酸酯（3）的绝对构型。此外，泽泻酮-B 23-乙酸酯（28）对用氯化钾预收缩的完整内皮胸主动脉环显示出强效的血管舒张活性。
Zotero 插件